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10 Best CBD Oil For Anxiety & Depression In 2024: Top Brands Reviews

Chelsea Rae Bourgeois

Updated on - Written by
Medically reviewed by Kathy Shattler, MS, RDN

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Anxiety disorders are believed to affect 34% of American adults[1] at some point in their lifetime. There are several ways to manage anxiety, including cognitive behavioral therapy and prescription medications. However, many people are now seeking more natural forms of treatment, and natural hemp has grasped their attention. But with so many CBD oil brands, what is the best CBD oil for anxiety? We’ve designed a list of what we believe to be ten of the top CBD oils for anxiety. In this article, we break down the science of CBD oils and their effects on anxiety disorders.

10 Best CBD Oil For Anxiety & Depression In (February. 2024)

Does CBD Help Reduce Anxiety And Stress?

While there’s still room for more research, current studies indicate that CBD can be helpful[2] for those who deal with stress and anxiety disorders. However, with the limited research we have, it’s not understood how CBD helps reduce anxiety. 

It’s believed that CBD interacts with the endocannabinoid system, but it’s unclear how. Some believe that it prevents the endocannabinoids from breaking down, allowing them to affect your system more.

10 Best CBD Oils For Anxiety, Depression & Stress In 2024

CBDfx CBD + CBN Oil Calming Tincture

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CBDfx offers many high-quality CBD products, including its CBDfx CBD + CBN Oil Calming Tincture. This full-spectrum CBD tincture harnesses the powers of CBD and cannabinol or CBN to help users feel calm and manage their anxiety.

  • Available in four strengths.
  • Third-party lab tested.
  • Full-spectrum
  • Contains a proprietary blend.
  • May not pass a drug test.

CBDfx CBD + CBN Oil Calming Tincture is a mixture of CBD, cannabinol, and a proprietary terpene blend, designed to help you calm down. It is available in four strengths, ranging from 1,000 to 6,000 milligrams of CBD per bottle, allowing customers flexibility depending on how much CBD oil they want to take at one time. 

Additionally, customers can choose between 150 milligrams or 300 milligrams of CBN per bottle. CBN is another naturally occurring cannabinoid and a by-product of THC that can bind CBN with receptors in the brain to promote calmness and sleepiness.

Researchers have also found that it works with other cannabinoids, like CBD and the rest of the cannabinoids in this full-spectrum product, to produce the entourage effect. They work synergistically with other cannabinoids and with terpenes to create a much more substantial impact than they would on their own. However, studies to date have shown no such sedating effect[3] on sleepiness or induction of a state of calm with the use of CBN by itself.

This full-spectrum CBD tincture from CBDfx is organic, vegan-friendly, and gluten-free. It has undergone testing by a third-party lab for its cannabinoid profile and most potential contaminants.  

CBDfx also offers a 60-day money-back guarantee, but products must be unopened or minimally used to qualify.

Joy Organics Broad Spectrum CBD Tincture

Joy Organics Broad Spectrum CBD Tincture

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Joy Organics has earned a positive reputation in the CBD industry for good reasons. Its Broad-Spectrum CBD Tincture is among the company’s best-selling products.

  • Available in four strengths.
  • Third-party lab tested.
  • Organic.
  • Only available in one flavor.

Joy Organics is certified organic by the United States Department of Agriculture and third-party tested for potency, purity, and safety.

The broad-spectrum formula is available in four strengths ranging from 15 to 75 milligrams of CBD per serving. It contains 0.0% THC but is rich in other cannabinoids, including CBN, cannabichromene, and cannabigerol. These cannabinoids work together to enhance the wellness effects of CBD oil. 

The Joy Organics broad-spectrum CBD oil tincture is vegan-friendly and has a tranquil mint flavor. 

Additionally, Joy Organics offers customers a 90-day satisfaction guarantee. If you find that broad-spectrum CBD potency doesn’t help with any of your anxiety-related disorders, you can return the product for a refund.

Spruce Lab Grade CBD Oil

Spruce CBD Oil

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Spruce CBD is made in the United States by a family business. The CBD company offers a wide range of products, including its lab-grade CBD.

  • Third-party lab tested.
  • Organic.
  • Full-spectrum.
  • Only available in one strength.
  • COA is not available online.
  • May not pass a drug test.

Spruce Lab Grade CBD Oil is 100% natural, containing only organic hemp seed oil, full-spectrum CBD oil, and natural flavors.

Unfortunately, this CBD oil is only available in one strength. Each bottle contains 750 milligrams of CBD, equaling 25 milligrams per serving. It is organic, vegan-friendly, and gluten-free. Additionally, it is free from artificial flavors, sweeteners, and preservatives. 

The CBD oil reportedly undergoes third-party lab testing. However, the certificates of analysis are not posted online. 

Because it is full-spectrum containing less than 0.3% THC, you may still not pass a drug screen, so best to choose broad spectrum or isolates (pure CBD) if you are being tested at work.

Spruce offers a 30-day money-back guarantee. However, the product must be returned unopened unless it is your first purchase.

Royal CBD Full Spectrum CBD Oil

Royal CBD Full Spectrum CBD Oil 1000mg

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Royal CBD’s full-spectrum formula is one of the company’s most popular CBD products. It can be used day or night to help promote calmness.

  • Four flavors are available.
  • Third-party tested for THC content.
  • Solvent-free.
  • Only one strength is available.
  • High cost per serving.
  • It may not pass a drug test.

The Royal CBD Full-Spectrum CBD Oil is a popular oil on the market today. The full-spectrum formula is available in one strength, equalling 33 milligrams of CBD per serving. Royal CBD offers this product in four flavors: natural, mint, berry, and vanilla.  

The formula is solvent-free, meaning Royal CBD does not use harsh solvents to extract the CBD. Instead, Royal CBD takes pride in using whole hemp extract, which contains higher concentrations of cannabinoids and terpenes. 

Third-party labs test Royal CBD products. However, the website only mentions that the products are tested to ensure THC levels are 0.3% or lower.

Even with subscription and bulk discounts, this CBD oil is one of the more expensive options on the market. However, Royal CBD offers a 30-day satisfaction guarantee.

Nuleaf Naturals CBD Oil

Nuleaf Naturals CBD Full Spectrum Oil

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Nuleaf Naturals sells a wide range of CBD products, including its full-spectrum oil. Made with just two ingredients, this CBD product can help reduce anxiety and improve calmness. 

  • Available in five sizes.
  • Contains two ingredients.
  • Full-spectrum.
  • Unclear 60-day guarantee.
  • Ten drops per serving.
  • May not pass a drug test.

Nuleaf Naturals CBD Oil is a full-spectrum product with only two ingredients; full-spectrum hemp extract and organic virgin hemp seed oil. It is made using an organic hemp plant and is available in five sizes ranging from 300 milligrams to 6,000 milligrams of CBD in the bottle. 

No matter what size bottle you purchase, Nuleaf Naturals recommends a starting dose of ten drops or 30 milligrams of CBD daily. The company also mentions the option to use it as needed. 

Customer reviews highlight experienced benefits, including reduced anxiety, improved sleep, and inflammatory pain relief. 

You can buy this CBD oil as a one-time purchase or set up a delivery subscription for 20% cost savings. Nuleaf Naturals offers a 60-day guarantee, but it’s unclear what it entails.

CBDistillery Full Spectrum CBD Oil

CBDistillery Full Spectrum CBD Oil

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CBDistillery’s Full-Spectrum CBD Oil is the company’s most popular CBD oil tincture. It can help users feel less discomfort and more relaxed after consistent use.

  • Third-party lab tested.
  • U.S. Hemp Authority-certified.
  • Only two ingredients.
  • Only available in one flavor.
  • May test positive on a drug test.

CBDistillery’s Full-Spectrum CBD Oil is available in bottles containing 1,000 milligrams of CBD, equalling 33 milligrams of full-spectrum CBD potency per serving. However, you can also purchase the same CBD oil at higher concentrations. 

It is made with non-genetically modified U.S. Hemp Authority-certified hemp, and the only other ingredients are a medium-chain triglyceride oil and natural terpenes. 

CBDistillery sends its products to undergo third-party lab testing to ensure they’re of the highest quality and have consistent serving sizes. 

If taking this CBD oil for anxiety or any other reason, CBDistillery recommends starting with 5-10 milligrams of CBD and then waiting three hours before adjusting your dose. However, the manufacturer recommends a dose of 30-60 mg/day for desired effects.

You can order the product as a one-time purchase or set up a delivery subscription for cost savings. Additionally, CBDistillery offers a 60-day satisfaction guarantee.

Medterra Isolate CBD Oil

Medterra Isolate CBD Oil

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Medterra is a well-known CBD company offering a wide range of high-quality products. However, its best-selling product is reportedly its Isolate CBD Oil.

  • Available in three strengths. 
  • Third-party tested.
  • U.S. Hemp Authority certified. 
  • Zero-THC.
  • Only the unflavored option is available.

Medterra’s Isolate CBD Oil has three strengths ranging from 500 to 6,000 milligrams of CBD per bottle. It’s made with 99% CBD and organic MCT oil. It can be taken during the day or evening to help reduce stress, improve sleep, and ease discomfort. 

The CBD isolate is made with organic, non-GMO hemp, and it undergoes third-party testing. Additionally, the product is certified by the U.S. Hemp Authority. 

Medterra recommends taking one full dropper daily or as needed. However, for maximum effectiveness, take over an extended period. Medterra Isolate contains absolutely no THC

You can buy the CBD isolate as a one-time purchase or set up a delivery subscription for 30% cost savings. Medterra also offers new customers a risk-free guarantee, which allows customers to try a product for 30 days.

CBDPure Full Spectrum CBD Oil

CBDPure Full Spectrum CBD Oil

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CBDPure’s Hemp Oil is a full-spectrum oil that blends phytonutrients, cannabinoids, terpenes, and more. It can help manage anxiety disorders and stress levels.

  • Available in three strengths.
  • Every batch is third-party tested.
  • Multiple options for cost savings.
  • Only unflavored are available. 
  • May not pass a drug test.

CBDPure’s full-spectrum formula has three strengths, allowing customers to decide how much of a therapeutic effect they want to experience. Unfortunately, the CBD product is only available as an unflavored oil, but customers can choose between bottles containing 300, 600, or 1,000 milligrams of CBD. 

CBDPure takes quality control very seriously. All ingredients are tested for pesticides, heavy metals, and other potentially harmful pathogens. Then, every batch of the full-spectrum product is tested by a third-party lab for both potency and purity.

You can buy this CBD oil as a one-time purchase or set up a delivery subscription for a 20% cost savings. You can also purchase the hemp oil in bulk for additional cost savings. And if you are unsatisfied with the product, CBDPure offers a 90-day money-back guarantee.

cbdMD Full Spectrum CBD Oil Tincture

cbdMD Full Spectrum CBD Oil Tincture

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Among the many CBD companies that comprise the industry today, cbdMD has a strong reputation. Its Full-Spectrum CBD Oil Tincture is a quality product that may help with anxiety and stress.

  • Third-party lab tested.
  • Available in two flavors.
  • Available in three strengths.
  • High cost per serving. 
  • May not pass a drug test.

The full-spectrum CBD tincture from cbdMD has three strengths and two flavors. Customers can order bottles that contain 1,500 milligrams, 3,000 milligrams, or 6,000 milligrams of CBD. Additionally, customers can choose between a chocolate mint or a natural flavor.  

The full-spectrum formula is made with MCT oil infused with full-spectrum hemp extract. It contains less than 0.3% THC, which should not cause users to feel high. However, cbdMD recommends purchasing broad-spectrum oils if you are concerned about passing a drug test. 

The CBD tincture is made with U.S. hemp and is vegan-friendly and gluten-free. In addition, the product undergoes third-party lab testing for quality and consistency. 

Order the full-spectrum oil as a one-time purchase or set up a delivery subscription for a 25% cost savings. cbdMD also offers a 60-day money-back guarantee if you aren’t happy with your order.

Savage CBD CBD Tinctures

Savage CBD sells many cheap CBD products. So if you’re looking for a CBD oil for anxiety, its CBD oil tinctures might be just what you need.

  • Four flavors are available. 
  • Available in three strengths. 
  • Third-party tested.
  • Many product options sold out.

Savage CBD offers CBD oil tinctures in four delicious flavors: cucumber mint, pink grapefruit, lemon-lime, and peach pear. Customers can also choose between three strengths, including 1,000 milligrams, 1,500 milligrams, and 2,000 milligrams per bottle. 

The full-spectrum tincture’s ingredients include MCT oil, hemp seed, full-spectrum CBD, essential oils, and terpenes. You can take the oil sublingually or mix it into various beverages. 

Unfortunately, many product options were sold out at the time of this article. However, its stock issues could be related to its very affordable costs. 

Compared to other CBD oils, Savage CBD’s full-spectrum tincture is one of the most affordable options in today’s market.

Lastly, Savage CBD sends all of its products to a third-party lab for testing.

What Is CBD? 

Although CBD is found in marijuana, it’s non-impairing, meaning it does not get you high. It can be derived from the Cannabis sativa plant, not to be confused with the marijuana grown for its THC content. Hemp is considered any part of the Cannabis sativa plant containing no more than 0.3% tetrahydrocannabinol, a substance in marijuana with psychoactive properties. 

Scientists are still learning how CBD affects the body, but the United States Congress passed the Agriculture Improvement Act in 2018, essentially legalizing CBD from hemp plants. However, some states have not adjusted their controlled substance acts, so legality varies. 

CBD can be found in many products, including lotions, oils, capsules, foods, and cosmetics. You might rely on these products for many reasons, but let’s focus on CBD’s effects on anxiety and stress.  

How To Choose The Best CBD Products For Anxiety

Not all CBD products are safe and effective, so you’re smart to do your research before buying CBD oil. We compiled this list based on criteria we felt addressed quality, safety, and transparency. In our search for the best CBD for anxiety, we considered the following:

  • Proof of third-party testing.
  • THC content according to the certificates of analysis.
  • Company certifications.
  • Overall ingredients. 
  • Product potency.
  • Indicators of brand reputation.

How To Use CBD Oil To Treat Anxiety

Discussing the implications with your doctor before taking CBD oil for anxiety and stress is important. However, most CBD companies recommend taking CBD oil daily and as needed to benefit from its purported health mechanisms. 

There are different ways to use CBD. You can take most CBD oils sublingually. Put the recommended amount under your tongue and hold it in place for 30 to 60 seconds. You will likely notice effects within a few minutes. Some CBD oils can be mixed into food or beverages, but results may take longer.

And if you can’t find an oil you feel comfortable taking out of the many CBD oil brands on the market, consider trying CBD gummies for anxiety

Precautions & Side Effects

Before taking CBD for anxiety, especially nonprescription CBD products, talk with your doctor or a knowledgeable clinician. CBD may interact with certain prescribed medications, over-the-counter drugs, vitamins, and supplements.

Commonly reported side effects[4] associated with the use of CBD products include the following:

  • Diarrhea
  • Tiredness
  • Changes in appetite
  • Weight changes

Research also indicates that you may need to be mindful of what you eat when it’s time to take CBD. For example, a 2020 study found[5] that eating high-fat foods can increase CBD concentrations in your blood, thus increasing the risk for side effects. 

Remember that the Food and Drug Administration does not regulate or approve nonprescription CBD products. Additionally, you should not use CBD products if you are pregnant, trying to conceive, or breastfeeding. 

Final Thought

The cannabis plant has been a focus recently as research continues to uncover its many potential health benefits. Some people use CBD oils with hopes of chronic pain relief. Others use it to improve their sleeping patterns. And many turn to the best CBD oils for treating anxiety symptoms. 

If you struggle with anxiety and want to try the natural hemp route, look for products tested by a non-biased lab and be mindful of your serving. Even the best hemp oil for anxiety should be tested for purity, potency, and consistency. 

And, of course, while many people find CBD oil effective for treating anxiety disorders, it’s imperative that you first seek guidance from a trusted healthcare professional before treating your symptoms.

Frequently Asked Questions

Is CBD legal to use?

Congress passed the Agriculture Improvement Act in 2018 that removed hemp from the federal Controlled Substances Act. However, while this act essentially legalized CBD from hemp on the federal level, some states have not removed it from their controlled substances acts. So legality may vary among states.

Is it safe to use CBD to treat anxiety?

There is still a need for more research, but current studies indicate that CBD is generally a safe component of anxiety treatment for the average healthy adult.

Does CBD help with anxiety?

Whether you manage a social anxiety disorder or any generalized anxiety disorder, CBD oils for anxiety may encourage calmness and reduce stress. They can also help improve sleep which researchers found is linked to anxiety levels.[6]

How long does CBD oil take to work for anxiety?

If taken sublingually, CBD oil users may notice positive effects within just a few minutes. However, most CBD companies recommend taking CBD oil daily to maximize its benefits over time.

Will you get high when using CBD oil for anxiety?

Hemp-derived CBD products that do not contain THC do not have psychoactive properties. Even the oils that do contain the allowable amount of THC do not contain enough THC to get you high. If you are worried about passing a drug test, consider trying a CBD isolate or broad-spectrum CBD products.


+ 6 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Szuhany, K.L. and Simon, N.M. (2022). Anxiety Disorders. JAMA, [online] 328(24), pp.2431–2431. doi:https://doi.org/10.1001/jama.2022.22744.
  2. ‌Skelley, J.W., Deas, C.M., Curren, Z. and Ennis, J. (2020). Use of cannabidiol in anxiety and anxiety-related disorders. Journal of the American Pharmacists Association, [online] 60(1), pp.253–261. doi:https://doi.org/10.1016/j.japh.2019.11.008.
  3. ‌Corroon, J. (2021). Cannabinol and Sleep: Separating Fact from Fiction. Cannabis and cannabinoid research. [online] doi:https://doi.org/10.1089/can.2021.0006.
  4. ‌Iffland, K. and Franjo Grotenhermen (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, [online] 2(1), pp.139–154. doi:https://doi.org/10.1089/can.2016.0034.
  5. ‌Crockett, J.C., Critchley, D., Tayo, B., Joris Berwaerts and Morrison, G. (2020). A phase 1, randomized, pharmacokinetic trial of the effect of different meal compositions, whole milk, and alcohol on cannabidiol exposure and safety in healthy subjects. Epilepsia, [online] 61(2), pp.267–277. doi:https://doi.org/10.1111/epi.16419.
  6. ‌Sarah Laxhmi Chellappa and Aeschbach, D. (2022). Sleep and anxiety: From mechanisms to interventions. Sleep Medicine Reviews, [online] 61, pp.101583–101583. doi:https://doi.org/10.1016/j.smrv.2021.101583.
Chelsea Rae Bourgeois

Medically reviewed by:

Kathy Shattler

Chelsea Rae Bourgeois is a Registered Dietitian Nutritionist with a background in fitness and athletics. She has worked as a dietitian in the clinical setting for the past seven years, helping a wide variety of patients navigate their health through nutrition. She finds joy in sharing her passions through her freelance writing career with the hopes of helping people embrace their health and live their lives to the fullest.

Medically reviewed by:

Kathy Shattler

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