Fact checkedFact Checked

This article is reviewed by a team of registered dietitians and medical doctors with extensive, practical clinical and public health experience.


Gut Connect 365 Review 2023: How Does it Help with Leaky Gut?

Healthcanal thumbnail

Updated on - Written by
Medically reviewed by Kimberly Langdon, MD

All articles are produced independently. When you click our links for purchasing products, we earn an affiliate commission. Learn more about how we earn revenue by reading our advertise disclaimer.

gut connect 365








  • Ingredients backed up with scientific-based research
  • Free from harmful elements
  • Allergen-free
  • No adverse side effects
  • 60-day money-back guarantee

Brand Information

  • Made by a certified medical doctor
  • Science-based ingredients
  • No preservative additives
  • High-quality customer service

Medical Benefits

  • Promotes healthy gut lining
  • Prevents leaky gut syndrome
  • Supports immune system
  • Keeping the digestive system healthy

About The Brand

Digestive issues have always been familiar to many. From constipation to indigestion, every human once complained about one of these problems. What if a product can help you deal with your digestive health concerns?

United Naturals is a manufacturer of high-quality dietary supplements. Their supplements mainly focus on the digestive system’s health. More specifically, their products promote a healthy gut lining, making people avoid leaky gut syndrome.

Dr. Vincent Pedre founded the company. He is the current Chief Wellness Officer at United Naturals. Their standard products include synbiotic 365, which promotes gut flora, and Gut Connect 365, which supports gut health and digestive health.

So how does Gut Connect 365 work? What are the benefits of taking such a dietary supplement? By reading our review of GutConnect 365, you will find answers to these questions.

Top Alternative Choices

Colon Broom

Colon Broom

See Colon Broom Reviews

Colon Broom Discount: Up to $60 Off + Free Shipping

  • Helps in weight loss
  • Improves general gut health
  • Aids weight loss
  • Relieves bloating
  • Information on third-party testing is lacking
  • Does not cater to all allergies
bio complete 3

Gundry MD Bio Complete 3

See Bio Complete 3 Reviews

Get The Deal

33% Off Exclusively With Our Exclusive Link

  • Promote gut health
  • Reduce glucose levels
  • Prevent gas bloating
  • Lacks clear ingredients list
  • Expensive
total restore reviews

Gundry MD Total Restore

See Total Restore Reviews

Get The Deal

30% Off Exclusively With Our Above Ambassador Link

  • Relieve bloating and discomfort
  • Control food cravings
  • Support lack of focus
  • Some may not see the results
  • Potential drug interactions

What Do We Like About Gut Connect 365?

GutConnect 365 (Gut Connect 365) is a dietary supplement manufactured by United Naturals. According to the manufacturer, it helps relieve the leaky gut syndrome symptoms.

The brain behind the product and the company is Dr. Vincent Pedre. He believes that the combination of Eastern and Western medicine is an effective way to address every patient’s needs.

United naturals state that Gut Connect 365 was made to nourish, strengthen, and protect the gut lining. As a result, one may acquire higher energy levels, improved mood, better weight management, and more.

The product contains nine superfoods in its ingredients, which were scientifically proven to address specific digestive issues effectively. Find out more about its components in this review of GutConnect 365.

Gut Connect 365 Ingredients Reviews 2023

Gut Connect 365 contains valuable ingredients, which work together to achieve its goal of promoting gut health. Most of them have anti-inflammatory and antioxidant properties. They also contain probiotics and antiviral compounds, which help boost the immune system. 

Gut Connect 365 ingredients include 5000mg of L-Glutamine, 500mg of quercetin dihydrate, 150mg of Slippery Elm Bark, 150mg of Organic Marshmallow Root, 150mg of N-Acetyl Glucosamine, 150mg of Deglycyrrhizinated Licorice root extract, 50mg of Aloe Vera Extract, 30mg of Maitake Mushroom Extract, and 20mg of Zinc Orotate.

Gut Connect 365 Ingredients Review

United Naturals also added additional ingredients so that anyone taking Gut Connect 365 will not have a hard time drinking it. Such ingredients include MCT Oil Powder, Stevia Leaf Extract, and natural flavors (vanilla and cinnamon flavors).

L-Glutamine (5000 mg)

L-Glutamine[1] is one of the Excellent Gut Connect 365’s ingredients. It has been shown to keep our intestinal epithelial lining in its healthy state. It also can repair the intestinal epithelial lining when it has been damaged.

In addition to that, L-Glutamine also helps in weight management. Specifically, people who had enough of it experienced higher energy levels, improved mood, maintained muscle mass, and supported digestive health.

What does it do to Gut Connect 365? According to research, the human body cannot produce enough L-Glutamine when he or it is experiencing stress. It is regardless of whether it is chronic or acute. Therefore, a dietary supplement such as Gut Connect 365 matters a lot.

Glutamine is a potent amino acid. Thus, it can be considered the most beneficial ingredient of gut Connect 365. It supports gastrointestinal mucosal growth, preventing the mucosal lining from getting damaged. It is primarily responsible for healthy cell regeneration, keeping the gut cells healthy.

Quercetin Dihydrate (500 mg)

Certain free radicals are causing a lot of damage within our body, including our digestive system. They destroy the proteins responsible for our immune system. Quercetin Dihydrate[2] comes to the rescue.

Quercetin Dihydrate can fight these free radicals, enabling your body to nourish, strengthen and protect the gut lining. As a result, there will be less destruction that can occur inside your intestines. Consequently, the body can now produce and retain more proteins as well as direct more resources to repair the permeability of the gut lining, making it more secure instead of leaky.

Quercetin Dihydrate has something more to offer. In one research, rats who had Quercetin Dihydrate treatment had healthier kidneys. Therefore, there is also a greater chance that such an ingredient can protect human kidneys.

Slippery Elm Bark (150 mg)

Slippery Elm Bark[3] is known for its beneficial effects in certain digestive health conditions, including constipation and diarrhea. It is also used as a traditional treatment for ulcers.

The effectiveness of Slippery Elm Bark in stomach ulcers was first proven through horses. Aside from that, it has also been helpful to more serious digestive system problems like constipation irritable bowel syndrome (IBS-C), constipated IBS (IBS-M), and inflammatory bowel disease.

Furthermore, this said ingredient also has antioxidant properties. Therefore, it does not only support digestive health but also positively affects our immune system.

Organic Marshmallow Root (150 mg)

The use of Organic Marshmallow Root[3] in the medical field already started during the Middle Ages. The first people who used it were the Ancient Greeks. They use it to soothe specific symptoms of their digestive health issues.

Recently, certain studies have shown proof that Organic Marshmallow Root can repair the damage found in our gut lining. It stimulates the growth of our intestinal cells. Those cells are called epithelial cells. Furthermore, Organic Marshmallow Root helps form a layer responsible for protecting our epithelial cells.

This job of Organic Marshmallow Root prevents gut damage in the future. It also plays a role in protecting our body from autoimmune disorders and improving our immune system’s overall state.

N-Acetyl Glucosamine (150 mg)

N-Acetyl Glucosamine[4] is a kind of monosaccharide, abbreviated as NAG. When it is in plants, its role revolves around forming cell walls, preventing bacteria from getting their way, especially if those bacteria started to crosslink with peptides and polymers. Its function combines with glucuronic acid if it works in the human body. Then, it results in hyaluronic acid.

The said acid is a major component of cells and collagen and cartilage, protecting the gut lining. Also, N-Acetyl Glucosamine has been seen to have some immunomodulatory effects through inhibited elastase release from a person’s white blood cells.

Aside from its gut health support, N-Acetyl Glucosamine is often used in osteoarthritis prevention and treatment. For instance, one research has been conducted, and it showed that NAG could improve cartilage health. This has been indicated by cartilage growth and turnover biomarkers.

Furthermore, NAG has been shown to be chondroprotective. It has an anti-inflammatory property, which reduces inflammation in joints. It also prevents chondrocytes’ destruction and can supplement the management of the symptoms found in multiple sclerosis.

Deglycyrrhizinated Licorice Root Extract (150 mg)

Deglycyrrhizinated Licorice root extract[5] has been already used as a treatment for common digestive system disorders by Egyptians during the Ancient period. In today’s generation, it has been found that this ingredient comes with multiple digestive health benefits. As such, Deglycyrrhizinated Licorice root extract is an antioxidant, antimicrobial, and immunoregulatory.

As an antioxidant, Deglycyrrhizinated Licorice root extract fights free radicals or bacteria found in our gut lining. As an antimicrobial, it can decrease the pathogens found in our intestines. It leads to a reduced chance of intestinal permeability, lowering the risk of acquiring leaky gut syndrome as it helps reproduce probiotics.

As an immunoregulatory ingredient, it reduces or treats arthritic symptoms. It is called “immunoregulatory” because arthritic symptoms are often part of autoimmune problems and a sign of leaky gut syndrome.

Additionally, people with low potassium levels may also benefit from Deglycyrrhizinated Licorice root extract, especially when consumed regularly. It further affects muscle mass, improving your energy level and muscle strength.

Aloe Vera Extract (50 mg)

A 50mg of Aloe Vera Extract[6] is considered a mild laxative. People used it as a mild laxative for more than a thousand years. It is an excellent complement to the organic marshmallow root.

Aloe Vera Extract can help you manage constipation as far as digestive health concerns. It can even help ease the symptoms that manifest during the episode of Irritable Bowel Syndrome (IBS) as well as inflammatory bowel disease. Though it does not work directly to nourish further, strengthen, and protect the gut lining, it can certainly remove certain digestive issues you may encounter.

Maitake Mushroom Extract (30 mg)

Maitake Mushroom Extract[7] is considered one of the most unique among all Gut Connect 365 ingredients. It carries an antiviral property, therefore fighting against viral infections that any human can acquire daily.

Though its antiviral effects may carry indirect health benefits concerning gut health, Maitake Mushroom Extract also carries a blood sugar-stabilizing effect. If one has high blood sugar, they may have difficulty experiencing the body’s natural healing process. In contrast with those who have a stable blood sugar level, their body will have more capabilities of fighting against certain types of bacteria, viruses, and infections, including the ones to be found in the gut.

Maitake Mushroom Extract also supports fat metabolism, which enables your body to support better weight management. Finally, it also contains anti-cancer properties along with vitamin B, vitamin C, amino acids, minerals, and fiber.

Zinc Orotate (20 mg)

Zinc orotate[8] is a form of zinc. Above all other forms, Zinc Orotate is the most absorbable, yet many people still experience a deficiency of such compounds.

Zinc deficiency may lead to certain consequences. For instance, one who is lacking zinc in his or her body may experience loss of appetite, diarrhea, and even loss of taste.

Research has been conducted and showed a positive result. For instance, it has been found out that Zinc Orotate was able to decrease the likelihood of developing leaky gut syndrome among children with diarrhea. Another research was also conducted among guinea pigs and rats. The results showed that they had a decreased intestinal permeability.

Other Ingredients

Aside from the nine superfoods included in Gut Connect 365 ingredients, United Naturals added additional materials to make the product fully manufactured. These additional ingredients are not harmful to health. Instead, it only helps the dietary supplement be easier to take.

The additional ingredients included in Gut Connect 365 are natural flavors, MCT Oil Powder, and Rebaudioside A (Stevia Leaf Extract). The natural flavors are vanilla and cinnamon. It makes the supplement tasty.

The role of MCT Oil Powder is to improve the blend of all the ingredients. It is also known for its benefits in heart health. Furthermore, it contributes to weight loss, letting Gut Connect 365 good for weight management.

Last but not least is the Rebaudioside A (Stevia Leaf Extract). Stevia Leaf Extract is a great source of a sweet taste. It is a natural sweetener, but it does not cause an increase in blood sugar levels. With that, you can start taking Gut Connect 365 without the fear of getting hyperglycemic or gaining many calories.

How Does Gut Connect 365 Work?

Gut Connect 365 was formed to help support your digestive system, particularly in your gut. It also helps improve and maintain the status of your immune system.

The nine ingredients mentioned above work together to achieve such a goal. The key is taking it consistently. Simply follow the recommended dosage to maximize the health benefits it offers.

There are a few additional ingredients added as well. It does not harm you. Instead, it helps your intake become easier.

gut connect 365

Gut Health Product

Gut Connect 365

  • Ingredients are supported by scientific research
  • Help you deal with digestive health concerns
  • A high-price product

The Pros

The pros of the product are not limited to its health benefits only. Here are other reasons why Gut Connect 365 is worth-trying.

  • All ingredients are backed up with research and scientific evidence
  • The creation of the product is headed by a certified medical doctor
  • Excellent customer service support
  • 60-day money-back guarantee

The Cons

If given all the pros, but one still decides not to buy the product, the reasons are probably the following.

  • The price is a bit higher
  • The product can only be bought on the official website
  • May interact with other drug medications

Health Benefits of Gut Connect 365

We took a deeper look at each Gut Connect 365 ingredient and its benefits. From there, we can see how they complement each other to give their fullest health benefits.

The anti-inflammatory properties found in many ingredients prevent inflammation that may occur in your gut lining. The antioxidant properties help your body fight toxins that can be found in nature. The antiviral and antibacterial property prevents the development a viral and bacterial infection that may happen in the digestive system.

It certainly helps reduce the symptoms of the leaky gut syndrome. It can reduce diarrhea, bloating, gas, and many more. It also helps manage symptoms of Irritable Bowel Syndrome and inflammatory bowel disease, another two common digestive conditions.

The supplement has something more to offer though. It has an effect on your overall health, as its power can even go to your entire immune system. Thus, it can reduce or relieve joint pain, improve muscle mass, and improves your sleeping pattern. Customers further report that they got a higher energy level, improved mood, and better weight management.

Is Gut Connect 365 Safe?

According to the manufacturer of Gut Connect 365 which is United Naturals, all the ingredients they use are well-chosen. All are pure, potent, and supported by scientific research. Moreover, they made their product friendly to most people with allergies.

As such, the Gut Connect 365 is dairy-free, lactose-free, soy-free, egg-free, shellfish-free, and gluten-free. Therefore, whether you are allergic to milk, eggs, and other substances related to what has been mentioned, this dietary supplement will not harm you.

Potential Side Effects

Although Gut connect is generally safe to use, we still strongly advise that you seek medical advice from your doctor before taking any dietary supplement. This is because some compounds may counter-interact with your existing health condition.

For instance, even the United Naturals advise people who are sensitive to monosodium glutamate to avoid glutamine. This is because our body breaks L-Glutamine into glutamate. Similarly, L-glutamine included in this dietary supplement may cause an undesirable effect on those who are taking glutamate-blocking drugs.

Gut Connect 365 Dosage: How To Use?

As a starting point, the recommended way of using Gut Connect 365 is to take one scoop of it. Mix it with 8 oz of water per day.

As you go along, you may increase the dosage. With 1 scoop of the supplement, you may mix it with up to 12 oz of water per day. Most consumers take this before having their lunch. However, you can also take it during breakfast.

Alternatives to Gut Connect 365

Although there are many positive reviews about Gut Connect 365, some people may still think of finding alternatives to the product. If you are one of them, here are our few inputs.

First, United Naturals have a different product yet similar effects to what the Gut Connect offers. They call it Synbiotic 365, and they made it a tag saying, “Advanced Probiotic Formula”. Its ingredients contain a combination of prebiotics, probiotics, and Vitamin B.

Gut Connect 365 Reviews: What Do Real Users Say?

When talking about real consumers’ Gut Connect 365 review, we can see that this product has gathered a lot of feedback. One of the most appreciated features aside from the health benefits it offers is its great taste. As one user said;

“As soon as Gut Connect is available to the public, I’m buying 3 bottles of this product for the taste…it’s so good, and it helps repair leaky gut.”

To support the manufacturer’s claim, many users also reported the same result. For instance, one customer said in his review;

“I just was super low energy. I was sleeping probably 12 hours every night. I was eating healthy but I’ve had issues with IBS and digestion for years so my mother was concerned and sent this. I’ve been taking it for about 2 weeks and I had the energy to work out today for the first time in months. I feel like a normal human again.”

Where To Buy Gut Connect 365?

If you want to purchase Gut Connect 365, we highly suggest going to the official website of United Naturals found at unitednaturals.com. From there, you will see the updated price of the product as well as the available promo (if there is any).

This practice will also let you avoid scams. In any circumstance, you want to spend your money with nothing in return, won’t you?

United Naturals products including Gut Connect 365 are packaged in one jar, three jars, and six jars. In most cases, you can save a lot if you order six jars.

The company also offers a referral program wherein you may refer the product to a friend. If they decide to buy, you will earn a commission.

Another great thing about the company is that they offer a 60-day money-back guarantee to all its customers. If you find that Gut Connect 365 is not working for you, you can reach their customer service and ask for a refund. They accept product returns even if you already consumed half of it.

The company’s customer service performs excellently. They have a fast response rate. For instance, they have live chat support available during weekdays, particularly from 9:00 am to 5:00 pm. Alternatively, you can call them through their telephone number at 844-794-7728.

Final Thought

This Gut Connect 365 review revealed that this supplement is a dietary supplement that promotes a healthy gut, leading you to become a healthier individual. The product is manufactured by the United Naturals, which was founded by Dr. Vincent Pedre. He is a certified medical doctor and the Chief Wellness Officer of the said company.

The manufacturer chooses their Gut Connect 365 ingredients. All are pure and potent, carrying lots of health benefits and helping support the gut and overall immune system. The nine superfoods found in the supplement bring benefits such as having a higher energy level, improved mood, better weight management, and reduced joint pain.

Aside from the health benefits that Gut Connect 365 offers, its manufacturer is also being admired for its excellent customer service. Furthermore, they also provide a 60-day money-back guarantee. If you find that the supplement is not working for you, feel free to contact them.

However, be sure to order the product right from their official website. Otherwise, you will not be eligible for a money-back guarantee.

Given that Gut, Connect 365 is made to nourish, strengthen, and protect our gut health and immune system, and they also have a high-quality service, we strongly recommend this product over others. Be healthy. Let this help you turn your life into 365 degrees.

However, if you have an existing medical condition, do not forget to seek medical advice before taking such supplements. This is due to the possible interaction with other drugs you are taking.

Frequently Asked Questions

Is Gut connect 365 legit?

Yes, Gut Connect 365 and its manufacturer United Naturals are both legit. There are no reported scams unless you do not buy the product from the official store. In addition, many positive reviews about the product can also be found on the net.

Is Vincent Pedre a real doctor?

Yes, Vincent Pedre is a Certified Medical Doctor. He obtained his degree at the University of Miami School of Medicine. He was also the founder of Pedre Integrative Health and focused on the holistic approach to dealing with his patients’ health and wellness.

What foods does Dr. Pedre say to avoid?

There are five primary food categories that Dr. Vincent Pedre says to avoid. These include foods with high amounts of gluten, dairy, soy, corn, and legumes.

When should I take Gut Connect 365?

Most of the customers of United Naturals are taking Gut Connect 365 before lunchtime. They are using it daily following the dosage guideline to maximize all the benefits. However, there are some that are taking it during breakfast.

Is Gut Connect 365 safe to use?

Yes, it is generally safe to use. According to research, the ingredients included in the said supplement are effective and do not cause adverse side effects. However, seek medical advice if you have other medical conditions.

Does Gut Connect also help with blood pressure?

As of the moment, there is a limited study regarding blood pressure and the ingredients in Gut Connect 365. However, the ingredients are found to not have the ability to increase blood pressure levels.

What are the symptoms of leaky gut syndrome?

The primary symptoms of the leaky gut syndrome include diarrhea, constipation, bloating, fatigue, and headache. If persistent, you may experience difficulty concentrating, skin problems, joint pain, and certain nutritional deficiencies.

+ 8 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Krishna Rao, R. (2012). Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. Journal of Epithelial Biology and Pharmacology, [online] 5(1), pp.47–54. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369670/ [Accessed 24 Mar. 2021].
  2. ‌Suzuki, T. & Hara, H. (2009). Quercetin Enhances Intestinal Barrier Function through the Assembly of Zonnula Occludens-2, Occludin, and Claudin-1 and the Expression of Claudin-4 in Caco-2 Cells. The Journal of Nutrition, [online] 139(5), pp.965–974. Available from: https://pubmed.ncbi.nlm.nih.gov/19297429/
  3. ‌Gustafson, C. (2016). Amie Skilton, nd, bhsc: Inflammation in the Gut Drives Systemic Inflammation. Integrative medicine (Encinitas, Calif.), [online] 15(4), pp.32–4. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991648‌/
  4. Sicard, J.-F., Vogeleer, P., Le Bihan, G., Rodriguez Olivera, Y., Beaudry, F., Jacques, M. & Harel, J. (2018). N-Acetyl-glucosamine influences the biofilm formation of Escherichia coli. Gut Pathogens, [online] 10(1). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013987/
  5. Peterson, C.T., Sharma, V., Uchitel, S., Denniston, K., Chopra, D., Mills, P.J. & Peterson, S.N. (2018). Prebiotic Potential of Herbal Medicines Used in Digestive Health and Disease. The Journal of Alternative and Complementary Medicine, [online] 24(7), pp.656–665. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065514/
  6. Foster, M., Hunter, D. & Samir Samman (2011). Evaluation of the Nutritional & Metabolic Effects of Aloe vera. [online] Nih.gov. Available from: https://www.ncbi.nlm.nih.gov/books/NBK92765/
  7. Lull, C., Wichers, H.J. & Savelkoul, H.F.J. (2005). Antiinflammatory and Immunomodulating Properties of Fungal Metabolites. Mediators of Inflammation, [online] 2005(2), pp.63–80. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160565/
  8. Skrovanek, S. (2014). Zinc and gastrointestinal disease. World Journal of Gastrointestinal Pathophysiology, [online] 5(4), p.496. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231515/
Healthcanal thumbnail

Written by:

Healthcanal Staff

Medically reviewed by:

Kimberly Langdon

HealthCanal Editorial team is a team of high standard writers, who qualified the strict entrance test of Health Canal. The team involves in both topic researching and writting, which are under supervision and controlled by medical doctors of medical team.

Medically reviewed by:

Kimberly Langdon

Harvard Health Publishing

Database from Health Information and Medical Information

Harvard Medical School
Go to source

Trusted Source

Database From Cleveland Clinic Foundation

Go to source

Trusted Source

Database From U.S. Department of Health & Human Services

Governmental Authority
Go to source


Database from World Health Organization

Go to source

Neurology Journals

American Academy of Neurology Journals

American Academy of Neurology
Go to source


United Nations Global Compact
Go to source

Trusted Source

Database From National Institute for Occupational Safety & Health

U.S. Department of Health & Human Services
Go to source

Trusted Source

Database from U.S. National Library of Medicine

U.S. Federal Government
Go to source

Trusted Source

Database From Department of Health and Human Services

Governmental Authority
Go to source

PubMed Central

Database From National Institute Of Health

U.S National Library of Medicine
Go to source