Best Milk Thistle Supplement Reviews In 2024: Top 5 Choices

Chelsea Rae Bourgeois

Updated on - Written by
Medically reviewed by Dr G. Michael DiLeo, MD

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Future Kind Vegan Milk Thistle Seed Liver Cleanse

Future Kind Vegan Milk Thistle Seed Liver Cleanse

  • Vegan-friendly.
  • Small tablet size.
  • Third-party tested.

10% Off Coupon: HEALTHCANAL

Life Extension Advanced Milk Thistle

Life Extension Advanced Milk Thistle

  • Rewards program.
  • Comes in a 30- or 60-day supply.
  • Easily accessible certificate of analysis.

Mary Ruths Organic Milk Thistle Seed Liquid Drops

Mary Ruth’s Organic Milk Thistle Seed Liquid Drops

  • Easy-to-take liquid form.
  • Third-party tested.
  • Certified organic.

Our bodies naturally rid themselves of toxins thanks to healthy liver function, but many people are searching for an organic solution to improve their liver function and support liver health. Implementing organic and natural supplements into your day may aid in liver productivity and longevity, all while increasing antioxidant properties.

Milk thistle extract is a popular supplement that may improve healthy liver function. Whether you partied a little too hard, have a family history of fatty liver disease, your diet lacks antioxidants, or you simply want additional liver support, milk thistle may be a supplement worth considering. In addition, people with a damaged liver, even damage caused by hepatitis or overuse of painkillers, may benefit from adding milk thistle[1] as a dietary supplement. 

This article will review five of the top milk thistle supplements on the market to help you in finding the best milk thistle supplement for your needs.

5 Best Milk Thistle Supplement Reviews In 2024

What Is Milk Thistle?

Milk thistle[2] is derived from a flowering plant native to Europe. The entire plant may be used in the supplement, but many benefits are found in the fruit and seeds. The most prominent natural ingredients in milk thistle are silymarin and silybin,[3] which may boost the immune response by acting as an anti-inflammatory, antioxidant, and anti-fibrotic agent. 

These two ingredients are often used interchangeably, but they have different purposes and effects on the body.[4] Silybin’s primary purpose is to help the body eliminate free radicals. Silymarin acts as an insulin sensitizer, anticarcinogen, antidiabetic, anti-fibrotic, and choleretic.

With these unique properties in tandem, milk thistle may reduce inflammation, toxins, and scarring on the liver. While most claims revolve around liver health, some companies promote milk thistle extract as a supplement that can support weight loss. However, there is very little research to back up those claims.

5 Best Milk Thistle Supplement Brands Reviews 2024

Future Kind Vegan Milk Thistle Seed Liver Cleanse

Future Kind Vegan Milk Thistle Seed Liver Cleanse

10% Off Coupon: HEALTHCANAL

See Future Kind Reviews

Future Kind Vegan Milk Thistle Seed Liver Cleanse tablet is small and easy to swallow. Plus, it’s vegan-friendly!

  • Vegan-friendly.
  • Small tablet size.
  • Third-party tested.
  • Must spend $70  before free shipping eligibility.

Future Kind, started by Aussie brothers Shaun and Eliot, aims to provide high-quality products for its customers without sacrificing environmental responsibility. Its Vegan Milk Thistle Seed Liver Cleanse is made under those same guidelines and is third-party tested for safety and quality.

The supplement tablet is smaller than most others on the market, making it easier to swallow. And even though the tablet is small, one tablet is a full day’s dose. Every serving of the Liver Cleanse supplement provides 175 milligrams of milk thistle seed extract and 275 milligrams of milk thistle seed powder. 

If you consider taking milk thistle extract for the first time, Future Kind’s 30-day money-back guarantee can give you peace of mind. With its money-back guarantee, Future Kind will provide you with a full refund (minus shipping costs) if you are unsatisfied with the product. 

However, based on reviews, Future Kind’s customer base appears to be very happy with its products. The strong following of consumers is likely a result of Future Kind’s speedy and helpful customer service and considerations for sustainable practices.

Future Kind customers also rave about their fast shipping and quick turnaround on orders. The only downside of this supplement is that you have to buy $70 worth of products to receive free shipping.

Life Extension Advanced Milk Thistle

Life Extension’s Advanced Milk Thistle aims to support liver health by aiding in the body’s natural detoxification process. Two swift gels daily provide a full spectrum of liver-supporting compounds.

  • Rewards program.
  • Comes in a 30-day or 60-day supply.
  • Easily accessible certificate of analysis.
  • Requires two soft gels a day.
  • Contains a proprietary blend.

Every serving of Life Extension’s Advanced Milk Thistle provides 760 milligrams of its milk thistle phospholipid proprietary blend and 160 milligrams of SILPHOS phytosome milk thistle extract. The phytosome milk thistle extract is said to help increase the bioavailability of silybin, one of the main active ingredients in this health supplement. 

While Life Extension Advanced Milk Thistle is a soft gel, the pills are large, and a full dose requires two daily capsules. These capsules should be taken at separate times of the day or as directed by your doctor. Therefore, this milk thistle supplement would be best suited for individuals who don’t mind taking medications multiple times a day and are comfortable taking larger pills.

Life Extension offers a rewards program, so the more supplements you purchase, the more discounts you earn. Advanced Milk Thistle can also be purchased as a 30- or 60-day supply, so you can customize your supplement schedule as you see fit while making money back. Lastly, the certificates of analysis for all of Life Extension’s products are easily accessible.

Mary Ruth’s Organic Milk Thistle Seed Liquid Drops

As the only liquid extract supplement on our list, MaryRuth’s Organic Milk Thistle Seed Liquid Drops make taking this type of supplement easier than ever.

  • Easy-to-take liquid form.
  • Third-party tested.
  • Certified organic.
  • Cost per dose.
  • Difficult to confirm the exact dose.

MaryRuth’s was founded by MaryRuth Ghiyam, a health educator and culinary chef. She set out to make quality liquid vitamins and now sells over 160 products, including her Organic Milk Thistle Seed Liquid Drops. Like all of MaryRuth’s products, the organic milk thistle drops are third-party tested for quality and safety. Furthermore, it’s certified organic, vegan-friendly, and alcohol-free. 

If you don’t like organizing your supplements and medications or having to pack large pill bottles, MaryRuth’s organic milk thistle seed extract might be the right fit for you. This convenient formula can be added to your daily water and can also be an excellent option for individuals who have trouble swallowing pills.

However, all of this convenience comes at a cost, as MaryRuth’s is one of the more expensive options on our list. Additionally, it is difficult to confirm your exact dosage because the dropper may not produce the same size drop each time.

GNC Herbal Plus Milk Thistle

GNC’s Herbal Plus Milk Thistle is highly concentrated, containing 1300 milligrams of milk thistle extract in every dose. With online and in-store availability, you can purchase this supplement anywhere, anytime.

  • Highly concentrated.
  • Cost-effective.
  • No artificial flavor, colors, or preservatives.
  • Large pill size.

GNC’s Herbal Plus Milk Thistle provides a highly-concentrated formula containing 1300 milligrams of milk thistle seed extract. This herbal supplement is made without artificial ingredients such as artificial flavors, preservatives, and colors. 

If you are suddenly running low on your supplements, you can either visit a store or choose same-day delivery for an additional fee. Or, if you like to plan ahead, you can order online, then pick it up in-store for an additional 15% off the purchase price.

The only con of the GNC Herbal Plus Milk Thistle is that the pill size is made of dehydrated herbs and is larger than some other supplements. This may make it slightly more difficult for some people to swallow.

Now Foods Milk Thistle Extract Extra Strength Softgels

Now Foods Milk thistle Extract, Extra Strength is one of the more cost-effective options on the market. Each dose provides 450 milligrams of milk thistle extract.

  • Easy-to-swallow soft gels.
  • Cost-effective.
  • Produced in a Good Manufacturing Practices facility.
  • Autoship is not available.
  • Safety and quality testing performed in-house.

Now Foods’ Extra Strength Milk Thistle supplement provides 450 milligrams of milk thistle extract in its one capsule serving, which is three times the amount in its standard milk thistle capsules. And since each bottle comes with 120 capsules, the price point of this product makes it a cost-effective contender on the list of best milk thistle for liver repair or fatty liver, …

At approximately $10 a month, Now Foods offers one of the lowest costs per serving for this type of herbal supplement. The soft gel consistency is another perk, making it easier to swallow and improving solubility.

Unfortunately, Now’s website does not have the option to set up auto-ship. So, if you tend to forget to renew your subscriptions, you might need to set a reminder for your monthly order. However, consumers can buy online or in-store, which makes purchasing this product convenient.

How Does It Work?

Milk thistle reduces inflammation by regulating cytokines, a bodily protein that works in the immune system. These anti-inflammatory properties are especially helpful in restoring liver function lost by alcohol consumption or fatty liver disease

Milk thistle may also serve as an antioxidant by protecting the body from toxins and free radicals, such as those from acetaminophen and ethanol. Lastly, it prevents collagen from collecting on the liver, which causes further damage in conditions like cirrhosis. 

Of course, it’s important to remember not all milk thistle products are made the same, and optimal health results will vary among individuals. Wellness supplements are most effective when coupled with well-balanced dietary and lifestyle habits.

Benefits Of Milk Thistle

Milk thistle supplements might be worth considering if you’re looking for health and wellness supplements that help you maintain healthy liver function. Milk thistle[3] is commonly used to promote healthy liver function as an anti-inflammatory, antioxidant, and anti-fibrotic. 

When taken consistently, milk thistle may reduce inflammation in the liver, help the body say goodbye to free radicals, and prevent and repair scarring on the liver. 

Milk thistle can be used as a proactive and reactive supplement, which may prevent and repair liver damage. Some customer reviews even said it helped reduce the effects of alcohol consumption afterward.

At this time, research also suggests a correlation between diabetes and milk thistle. In addition, early studies suggest that milk thistle could improve insulin resistance[5] in individuals with diabetes. However, studies are still being conducted on its efficacy in reducing diabetic symptoms, so it is recommended that those with blood sugar irregularities use caution when taking milk thistle.

Are There Any Downsides?

Research continues to explore the benefits and potential risks of milk thistle seed extract. Results seem to vary based on each individual, so it is important to monitor side effects and progress over the first month of taking milk thistle supplements. 

Common side effects of milk thistle include gastroenteritis, diarrhea, headache, rash, or hives. As with many herbal supplements, there isn’t a commonly agreed-upon dosing recommendation for milk thistle extract. So, it’s important to discuss this with your doctor, especially if using other medications or if you have medical conditions. 

Side effects may be more common in those with a history of an allergic reaction to plants in the same line as milk thistles, such as daisies, ragweeds, marigolds, and chrysanthemums. It is unknown how milk thistle may interact with prescribed medications, so discussing potential drug interactions with your doctor or dietitian before adding milk thistle supplements to your wellness routine is important.

Buying Guide: What To Look For The Best Milk Thistle Brand?

If you’re wondering what to look for when buying milk thistle supplements, consider its ingredients, dosage, and cost. Some milk thistle makers will include various ingredients that can affect both your physical reaction to the product and its marketing price. 

The best brands of milk thistle will include silybin and silymarin, the two ingredients in milk thistle that give it its purportedly positive liver-protecting benefits. Check the health label on the back of the product for specific ingredients, especially if a product boasts of using a proprietary blend. 

After consulting with your doctor or dietitian, search for a milk thistle brand that offers their recommended dose. Doses offered typically range from 450 milligrams to 1300 milligrams. After finding a product that meets your doctor’s recommendation, decide if you prefer a tablet, soft gel, or liquid solution. Finally, determine if you want to take the supplement once or twice a day, and make sure your chosen brand meets your preference.

Final Thought

A milk thistle supplement could be a natural remedy if you want to improve your overall health by supporting your liver function. Milk thistle supplements have become increasingly popular, as they are seen as a natural, organic solution to help rid the body of unwanted toxins. 

Individuals who want to support the body’s natural waste elimination processes rarely want to add more toxins to the body through medication, so milk thistle extract has become a popular alternative. However, consult your doctor before taking milk thistle or changing any medicines.

Because milk thistle’s efficacy is still being studied, talk with your doctor and abide by their recommendations, especially for those with a history of liver diseases. It is also important to note that, like all dietary supplements, milk thistle is not regulated at all by the US Food and Drug Administration; thus, the FDA cannot recommend it as a treatment for any medical condition.

Frequently Asked Questions

What is milk thistle supplement used for?

Milk thistle may support the work your liver already does for you by helping it rid the body of unwanted toxins. It’s primarily an anti-inflammatory, antioxidant, and anti-fibrotic for the liver. Because of its antioxidant effects, researchers are studying the potential impact that milk thistle can have on cancer.

Who should not take milk thistle?

People with diabetes, pregnant and breastfeeding women, or those with environmental allergies should use caution when taking milk thistle. Further scientific research is needed to study the effects of milk thistle supplements in these populations.

Can I take a milk thistle supplement every day?

Yes, milk thistle is considered generally safe for the average adult to take daily. However, it’s important to discuss health implications with your doctor before starting any new wellness or herbal supplements.

What is the best way to use milk thistle?

Milk thistle can be used as a proactive and reactive supplement, meaning it may prevent and repair liver damage.

What is the best milk thistle supplement?

The best brand of milk thistle will vary among individuals. Choosing one of the best milk thistle supplements takes into account price, dosage, and safety testing.


+ 5 sources

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  1. Abenavoli, L., Capasso, R., Milic, N. and Capasso, F. (2010). Milk thistle in liver diseases: past, present, future. Phytotherapy Research, [online] 24(10), pp.1423–1432. doi:10.1002/ptr.3207.
  2. Milk thistle (no date) National Center for Complementary and Integrative Health. U.S. Department of Health and Human Services. Available at: https://www.nccih.nih.gov/health/milk-thistle.
  3. George, T. and Patel, R.K. (2022). Milk Thistle. [online] Nih.gov. Available at: https://www.ncbi.nlm.nih.gov/books/NBK541075/.
  4. Federico, A., Dallio, M. and Loguercio, C. (2017). Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules, [online] 22(2), p.191. doi:10.3390/molecules22020191.
  5. MacDonald-Ramos, K., Michán, L., Martínez-Ibarra, A. and Cerbón, M. (2021). Silymarin is an ally against insulin resistance: A review. Annals of Hepatology, [online] 23, p.100255. doi:10.1016/j.aohep.2020.08.072.
Chelsea Rae Bourgeois

Medically reviewed by:

Michael DiLeo

Chelsea Rae Bourgeois is a Registered Dietitian Nutritionist with a background in fitness and athletics. She has worked as a dietitian in the clinical setting for the past seven years, helping a wide variety of patients navigate their health through nutrition. She finds joy in sharing her passions through her freelance writing career with the hopes of helping people embrace their health and live their lives to the fullest.

Medically reviewed by:

Michael DiLeo

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