7 Best Wrinkle Cream & Serum For Anti-Aging 2022

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Medically reviewed by Kathy Shattler, MS, RDN

Clinique Smart Clinical Repair Wrinkle Correcting Serum

Clinique Smart Clinical Repair Wrinkle Correcting Serum

  • Ideal for all skin types
  • Sorts out fine lines
  • Fragrance-free

Murad Targeted Wrinkle Corrector

Murad Targeted Wrinkle Corrector

  • Hydrates skin
  • Smoothens forehead lines
  • Immediate results

Olay Regenerist Micro-Sculpting Cream

Olay Regenerist Micro-Sculpting Cream

  • Affordable
  • Easy to purchase
  • Hydrates skin

Beauty brands are always developing revolutionary cosmetic products using scientific research. The hunt for the best wrinkle cream and serum has become a global goal for both women and men wanting to stay youthful even in their golden ages.

Ideally, there is a wrinkle cream and serum for each skin type and skin tone. The three main skin types are dry[1], oily[2], and sensitive skin[3]. And the various skin tones are light, fair, medium, and dark. Some people have a combination of two or all skin types called combined. Regardless, you can find an anti-aging wrinkle cream that will fit each skin type.

Wrinkle creams and serum contain numerous beneficial ingredients like hyaluronic acid, alpha hydroxy acids, vitamin C, vitamin E, etc. These active ingredients have innumerable benefits like

  • Improved skin tones by evening them out by brightening[4] the dark spots to give you fair skin
  • Improved skin elasticity[5]
  • Improving skin texture
  • Protecting the skin against harsh sun rays[6]
  • Restoring skin health from the sun and chemical damage[7]
  • Stimulating collagen production
  • Removing dead skin cells and rejuvenating skin cells

They may also improve the appearance of fine and deep lines, usually around the eyes, mouth, and nose.

 The overall effect is smoothing wrinkles, giving your skin a plump, youthful look and feel.

Let’s look at why our skins will appreciate the use of these wrinkle creams and seven of the best wrinkle creams and serums.

Best Wrinkle Cream & Serum For Anti-Aging On The Market In (May. 2022)

The Line Up At A Glance

Clinique Smart Clinical Repair Wrinkle Correcting Serum

Editor’s choice

Clinique Smart Clinical Repair Wrinkle Correcting Serum

  • Ideal for all skin types
  • Sorts out fine lines
  • Fragrance-free

Murad Targeted Wrinkle Corrector

Best Wrinkle Cream For Forehead

Murad Targeted Wrinkle Corrector

  • Hydrates skin
  • Smoothens forehead lines
  • Immediate results

Olay Regenerist Micro-Sculpting Cream

Best Anti-Aging Moisturizing Cream

Olay Regenerist Micro-Sculpting Cream

  • Affordable
  • Easy to purchase
  • Hydrates skin

SkinCeuticals A.G.E. Interrupter

Best Elasticity-Boosting Anti-Aging Cream

SkinCeuticals A.G.E. Interrupter

  • Boosts skin elastin
  • Boosts skin hydration
  • Ideal for dry skin

Derma Progenix

Best Affordable Anti-Aging Serum

Derma Progenix

  • Affordable
  • Protect skin from Ultraviolet (UV) rays
  • Made in Good Manufacturing Practices (GMP)-certified labs

Jurlique Nutri-Define Supreme Eye Contour Balm

Best Anti-Aging Eye Cream

Jurlique Nutri-Define Supreme Eye Contour Balm

  • Eliminates dark circles
  • Contains ball massager
  • Suitable for all skin types

Skinbetter Science AlphaRet Overnight Cream

Best Wrinkle Night Retinoid Serum

Skinbetter Science AlphaRet Overnight Cream

  • Rich in retinoids
  • Improves skin texture
  • Smoothens fine lines

Do We Need To Use Anti Wrinkle Creams?

The skin is the largest organ in the body, so it needs protection[8] from external pathogens and factors that could damage it. Sun damage, dehydration, acne, and aging are some of the issues we aim to sort out.

The use of sunblock can avoid sun damage, evidently shown with sunburn patches and the development of brown sunspots. Dehydration commonly presents as cracked, shiny skin and can be smoothed by hydrating the skin using moisturizers and drinking water. But skin aging, which manifests as fine lines and wrinkles, needs more care than the obvious ones above.

Skin wrinkles are usually a result of reduced skin elasticity due to low collagen production. Collagen[9] is a protein that is essential for skin elasticity. It makes up three-quarters of your skin and a third of the protein content in your body. As you get older, the collagen in your system breaks down, making it more difficult for your system to create more.

Wrinkle creams and serums may help protect the skin and keep you looking young, fair, and supple.

Before we get to the seven best creams for deep wrinkles, let’s briefly cover what serums are.


Unlike wrinkle creams that contain various active ingredients, serums[10] are concentrated anti-aging ingredients usually made from only one component with a specific purpose.

The general types of serums sold are-

  • Retinoids are Vitamin A[11] compounds that promote cell renewal and collagen synthesis, decreasing wrinkles and hyperpigmentation.
  • Peptides are made up of amino acids[12], are the foundations of collagen, and can help smooth wrinkles and firm up the skin.
  • Niacinamide is a vitamin B3[13] derivative that brightens and helps balance skin tone, increases collagen formation, and reduces inflammation.
  • Hyaluronic acid[14] is a potent hydrator and plumper for the skin.
  • Antioxidants[15] like green tea, vitamin E, vitamin C,  and resveratrol protect the skin from harm from free radicals and inflammation. Free radicals are unstable atoms that damage the cells, causing aging.

7 Best Anti Wrinkle Creams For Smooth & Tight Skin in 2022

Clinique Smart Clinical Repair Wrinkle Correcting Serum

The revolutionary recipe is remarkably blended with anti-aging experts, including the expert company’s unique CL1870 Laser Focus Complex, a peptide-rich mix, strong retinoid, and potent hyaluronic acid. The blend was created with the help of an advisory group of researchers and dermatologists.

  • It is a fragrance-free cream.
  • It may help rejuvenate skin in aging, wrinkling, and the development of fine lines
  • It contains ingredients for facial rejuvenation and skin cell healing
  • It helps get rid of irritation and brightens the face
  • It is an expensive anti-aging serum

Its mode of action is that it tackles the fine facial lines and imperfections from three different angles to cover the entire extent of wrinkles and fine lines.

It contains CL1870 Laser Focus Complex, an anti-aging serum that boosts collagen production. With a powerful retinoid[11], it plumps up, polishes, and smooths skin. It also hydrates subtle wrinkles with hyaluronic acid, which helps to firm the skin barrier.

After using it for a while, you may notice that your skin seems to be revitalized, softer, and smoother to the touch, with a more youthful glow.

It’s a quick-acting skin serum, with benefits visible in as little as ten days.

The ingredients are:

  • CL1870 Laser Focus Complex: An expert blend of peptides and optimizing ingredients that work together to enhance the skin’s natural collagen synthesis and strengthen its support structure.
  • Pure retinoid: The next grade of retinol, developed for high-performance anti-aging properties while remaining mild. It aids in the cellular membrane renewal of the skin, allowing new skin cells to reach the surface faster. It also visibly minimizes the appearance of wrinkles and assists in shedding dull top skin.
  • Hydrates and plumps skin instantly with hyaluronic acid[16] concentrate. It works by decreasing the amount of fine, dry lines by helping to reinstate firmness and density.

Murad Targeted Wrinkle Corrector

This brand is the best wrinkle cream for women since it is fast-acting. You notice your facelift in just one application, and the fine lines, wrinkles, and crepey skin disappear.

  • You will see results with the first application
  • It is ideal for a quick application, which makes makeup flawless
  • It is perfect for all skin wrinkling concerns
  • The changes are temporary
  • The product expires in a short time

If you are short on time to head to the dermatologist for some fillers, this brand does it for you in one application. In an instant, it fills up all the skin creases, hydrates it, makes it look and feel smoother, firmer, and moisturized.

The only downside is that these effects are temporary. You will need to reapply after a few hours since everything will bounce back to its original appearance.

Because of these three active ingredients, the magical cream performs wonders:

  • Acetyl hexapeptide-8 improves elasticity[22], which helps to avoid future wrinkles caused by frequent facial expressions.
  • Hyaluronic acid is bioavailable and does a great job moisturizing the skin to appear plump and soft and eliminates wrinkles.
  • Squalane[34], which is derived from plants, helps the skin resist wrinkles in the future.

Please apply to freshly cleansed, dry skin and dab into the crease with the metallic applicator and, if necessary, your middle finger for the best outcomes. Make sure you don’t rub it in. Let the product completely dry before adding serums, moisturizers, or makeup.

Olay Regenerist Micro-Sculpting Cream

This anti-aging cream may be the best wrinkle cream for men because they have a non-fragrant cream that men may prefer to use.

  • It’s both cheap and easy to get
  • The formula is hydrating
  • There is a fragrance-free version
  • It contains parabens

This cream contains the following:

  • Amino-Peptide Complex II[20]: Because amino acids are rich in elastin, collagen, and keratin, amino peptides are vital for maintaining skin rigidity.
  • Niacinamide (Vitamin B3): This water-soluble nutrient can help reduce pore size, balance sebum production[35], make uneven skin tone fairer, and smooth out fine facial lines and wrinkles.
  • Hyaluronic Acid: This skin-favoring acid is the trendiest substance right now, and for a good reason. The humectant (hydrator)  is the perfect moisturizer since it can hold 1,000[36] times its weight.

The product is suitable for all skin types, but those with sensitive or dry skin should choose fragrance-free versions. Fragrances tend to make the skin drier.

SkinCeuticals A.G.E Interrupter

The anti-aging wrinkle cream may reduce the appearance of fine lines, curb skin thinning, and elasticity damage from A.G.E. (advanced glycation end-products.)

  • It is a lightweight cream
  • It is ideal for all dry skin types
  • It has potent anti-aging ingredients
  • It contains powerful antioxidants that eradicate harmful skin free radicals
  • It may improve skin texture, elasticity, and brightness
  • It works quickly with results after a few weeks of application
  • It is an expensive anti-aging cream

Because of its unique capacity to prevent wrinkles formation, the A.G.E. Interrupter is best for mature skin therapy that aids the reversal of the visible loss of suppleness and firmness. The breakdown of healthy elastin and collagen fibers that keep the skin smooth, tight, and plump is caused by A.G.E., proteins that are markers for aging and disease.

This anti-wrinkle treatment contains an unparalleled 4% blueberry extract, 30% proportion of ProxylaneTM, and 0.2 percent phytosphingosine to try and restore noticeable skin rigidity lost due to the glycation cycle. Glycation is caused[37] when sugars and proteins combine irreversibly to initiate inflammation and cellular damage.

Here is what the anti-wrinkle treatment does for the skin:

  • 4 percent Blueberry Extract: This naturally produced extract strengthens[38] the skin barrier and deters wrinkles and laxity by acting as an antioxidant and anti-glycation agent.
  • 30% of the total Proxylane™: Is designed to enhance the skin’s own Glycosaminoglycans[39] (G.A.G.) production while also rehydrating and nourishing it. G.A.G.s are hydrophilic skin cells that draw water into the skin to moisten it. They help keep the skin supple, elastic, and firm.
  • 0.2 percentage point Phytosphingosine: Phytosphingosine[40] is a naturally occurring substance that aids in the skin’s natural barrier recovery process and serves to preserve the skin’s barrier by reducing the irritation connected to dry, aged skin.

These ingredients help with reducing skin creping and thinning. So the cream may help improve the look of smile lines, creases, and skin texture in a noticeable way.

To improve the appearance of skin firmness, it replenishes water and nutrients.

Derma Progenix

Derma Progenix is a high-tech serum with vitamins and hydrating ingredients. It aids in collagen formation, which helps repair the skin. The product is composed of natural substances that are vitamin and nutrition-rich. It helps to nourish the skin while also protecting it from toxins.

  • Made in a GMP-certified lab
  • 60-day money-back guarantee
  • Wrinkles, fine lines, and dark circles are all reduced
  • Prevents the skin from discoloring
  • Protects the skin from irritation, peeling, and cracking
  • Prevents dryness by moisturizing the skin
  • Only available for purchase through the manufacturer’s official website
  • It’s always in limited stock due to high demand

The ingredients in Derma Progenix are all-natural, fully safe, and have no adverse effects. All of Derma Progenix’s ingredients are as follows:

  • Phenoxyethanol[17] is a disinfectant that kills microorganisms. It can aid in the treatment of acne-prone skin.
  • Ethylhexylglycerin[18] is a substance that aids in the appearance of younger skin.
  • Palmitoyl Tetrapeptide-7[19] (Palmitoyl Tetrapeptide-7) is an anti-aging substance. It boosts the production of amino acids, which aids in the healing of injured skin.
  • Acetyl Glutamyl Heptapeptide -1 clears out the fine lines on your forehead and around the eyes caused by muscle tension. The peptide[20] can effectively remove any wrinkles in a short period.
  • Palmitoyl Oligopeptide[21] is an ingredient that aids in improving skin cell health. It boosts collagen production and helps the skin appear softer and youthful.
  • Benzylamide Diacetate is a peptide that helps to prevent wrinkles and fine lines. This peptide is recognized for reducing face expression creases.
  • Hyaluronic acid helps to reduce wrinkles, hydrate the skin, erase dark spots, and moisturize and soothe dry skin.
  • Pentapeptide-18 is a peptide made up of five different amino acids. These peptides help to reduce the appearance of wrinkles induced by facial movements.
  • Acetyl Hexapeptide-8[22] can prevent wrinkles by preventing excessive muscle activity. By boosting collagen production, it smoothes and hydrates the skin.
  • Purified water hydrates and smoothes the skin. It also maintains the health of the skin cells.
  • Seaweed Extract[23] is high in vitamins and nutrients, which helps the skin remain supple and smooth. It hydrates the skin while also reducing irritation. It contains numerous anti-inflammatory qualities that are beneficial to the skin.

Seaweed extract tightens the skin, making it appear more appealing. Exfoliant qualities are also present in this extract. Furthermore, it revitalizes the skin by removing the dullness.

Since the ingredients are gentle on the skin, it is hands-down the best wrinkle cream for sensitive skin. This is mostly because of the healing properties that most ingredients included have on the skin.

Jurlique Nutri-Define Supreme Eye Contour Balm

The eye contour balm[24] manufacturers created it to address several indications of aging and rejuvenate the whole eye contour. The eye balm is formulated with potent botanicals to combat the signs of aging.

  • Ideal for all skin types
  • May prevent wrinkle formation around the eyes
  • It contains powerful botanical ingredients
  • The scent may be unpleasant to some users

Deep wrinkles, dark circles[25], and crow’s feet around the eyes are noticeably improved with this thick, high concentrated anti-aging eye balm. The Nutri-Define Supreme Eye Contour Balm aims to target indications of skin aging around the eye area.

For maximum absorption of the anti-aging balm by the surface of the epidermis, the brand has included botanical ingredients rich in antioxidants.

Jurlique has incorporated its own Advanced Biosome encapsulation of horseradish root extract, Spilanthes Flower extract[26], and Jurlique Botanical Blend for best absorption into the skin.

The contoured areas appear to be more toned and sculpted. After using this eye cream, users can expect fewer signs of exhaustion around the eyes, like annoying eye bags, distinct crows’ feet, and dark circles. The illuminance of the eye area is also restored.

Skinbetter Science AlphaRet Overnight Cream

This brand promises that its overnight cream works thanks to its broad and beneficial ingredient profile.

  • It is rich in retinoids
  • May smoothen fine lines and wrinkles
  • It is a lightweight cream
  • Fragrance-free
  • It is a cruelty-free wrinkle cream
  • It is quite expensive

To understand how AlphaRet Overnight Cream works, we must first evaluate its major ingredients.

Alpha Hydroxy Acids (AHAs)[27] included here are glycolic and lactic acid. AHAs exfoliate the skin by shedding corneocytes (dying or dead skin cells). The cell turnover rate is raised by boosting their disintegration and dispersion, resulting in smoother, brighter, and more even skin tone.

Ethyl Lactyl Retinoate: The lactic acid[28] in AlphaRet Overnight Cream is coupled with a retinoid, listed as ‘ethyl lactyl retinoate’ on the ingredient list. Retinoids can reduce the occurrence of fine lines and wrinkles, enhance uneven skin complexion while increasing suppleness, and reduce enlarged pores.

Tetrahexyldecyl Ascorbate (Vitamin C) donates charged particles to counteract reactive oxygen species (ROS) like superoxide ions and peroxide produced by UV exposure. It’s significant because ROS damages cellular DNA, membranes, and proteins, including collagen. Damaged collagen causes premature skin aging indicators such as wrinkles, lines, and drooping.

  • Vitamin C also promotes new collagen production[29] in the skin. Increased collagen levels reduce wrinkles and tighten the skin.
  • Vitamin C inhibits tyrosinase[30], an enzyme necessary for melanin synthesis. The outcome is brighter skin with fewer dark patches and an even tone.

Antioxidants: Other potent antioxidants in AlphaRet Overnight Cream include ubiquinone, vitamin E, and superoxide dismutase.

  • Ubiquinone[31] (coenzyme Q10 also known as CoQ10) application to the skin acts as an antioxidant, counteracting short-term ambient oxidative stress and age-related CoQ10 deficiencies.
  • Superoxide dismutase[32] (SOD) helps superoxide-free radicals dismutate into hydrogen peroxide and oxygen. Topical superoxide dismutase shields cell membranes and types I collagen from damage caused by free radicals.

Niacinamide’s[33] anti-aging properties include restoring the skin barrier and improving skin hydration.

How To Choose The Best Cream For Deep Wrinkles?

With the wide variety of anti-aging products in retail, it’s common to question what is the best wrinkle cream on the market, perfect for your skin kind. So here is a criterion with a few suggestions you can use to decide on the best cream for women and men:

Consider Your Skin Type

Similar to selecting other cosmetics like makeup, your skin type is fundamental in helping you choose an anti-aging cream and serum. The general types are oily, dry, sensitive, and mixed skins.

The product you should get must be specific to your skin type for the best results. And if you are not certain of the type you have, ensure to consult a professional or dermatologist for a thorough examination.

When you read the labeling of the deep wrinkle night cream or the anti-aging neck cream, ensure that it is for your skin type. It’s essential since all anti-aging products are typically sold for dry skin, sensitive skin, and oily skin.

Consider the Skin Concerns You Want to Sort Out

Here you must look at the specific active anti-aging ingredients included in the product.

Some people have dark spots due to hyperpigmentation caused by acne wounds or dark circles around their eyes. This group of people will then need to look for skin products for anti-aging with potent antioxidants that fade dark spots, brighten up the skin and offer a fair tone. So the best creams for them need to have brightening elements, and the best serums must be niacinamides and retinoids.

If you seek to smooth lines, even out uneven skin texture, boost collagen production, better skin elasticity, and even cure acne, get the product that is a solution to your problem.

Consider the Location and Time of Application

Any board-certified dermatologist will attest that sometimes using a skin product at a specific time and location is the best way to solve significant skin concerns. That is why you get anti-aging products specified for day and night applications. Each selection is fine-tuned to eye creams, hand creams, neck creams, and even body and serums.

Wrinkles appear almost everywhere in the body when we age. However, the visible wrinkles are primarily on our faces, neck, and hands. So when you are fighting wrinkles, select your anti-aging cream or serum, knowing when and where to apply it. For example, you would not buy an expensive face cream to treat your entire body or wear a night cream before applying makeup in the morning.

How to Maximize the Benefits of Wrinkle Creams?

Skincare usually goes beyond simply getting the best anti-aging wrinkle cream. You must do certain things to maximize the benefits of wrinkle creams and serums.

Here are the important ones:

Maintain Skin Hygiene

Even the best product backed up by cosmetic and clinical research will not work if you have dirty skin!

When your skin is dirty, applying cream or serum is a waste. You are simply piling up more layers that mix with dead cells and dirt, resulting in an unpleasant result.

You must have an anti-aging skincare routine that starts with cleansing, where you remove the dead skin cells. You may use facial scrubs and masks to do this. You also need water and mild skin soap to rinse off the dirt and dead skin cells.

Have an Anti-Aging Skincare Routine

It may seem like a lot at first, but your skin will thank you later.

A typical skin routine involves cleansing, moisturizing, and protecting. A further and detailed breakdown should follow the following order:

  1. Cleanse the skin.
  2. Use an anti-aging toner.
  3. Use an anti-aging serum.
  4. Use an anti-aging eye cream.
  5. Use dark spot treatment.
  6. Use a moisturizer.
  7. Apply retinoid.
  8. Apply face oil.
  9. Apply a broad-spectrum sunscreen[41] with an appropriate sun protection factor (SPF) as per where you are.

Follow this order if you want spotless skin with better elasticity and faded fine and deep wrinkles. These steps help the skin shed off old dead cells and create new skin cells for an entire facial rejuvenation.

Remember to use day creams for the day and night creams for the night.

Lastly, be consistent with this skincare routine to see results.

Final Thought

As you search for an anti-wrinkle cream, be sure that it matches your skin type; otherwise, it might not work. Secondly, read the ingredients and find out what each does. Lucky for you, we have done that for you for these seven brands.

Finally, have and religiously follow a skincare routine. It helps maximize the effectiveness of anti-aging creams and serums.

Frequently Asked Questions

Can creams really remove wrinkles?

Yes, they can. However, you must ensure that they are anti-aging creams with active ingredients that smoothen, hydrate, and boost the skin’s collagen production.

At what age should I start using wrinkle cream?

Prevention is always better than cure, so starting in your 20s can be beneficial later.

What is the best cream to get rid of wrinkles?

You can find various wrinkle creams from eye creams, hand creams, and face creams. The best product in the list above is Clinique Smart Clinical Repair Wrinkle Correcting Serum.

Can you reverse deep wrinkles?

Yes, you may see positive results shortly after starting with the best cream for deep wrinkles and consistent application on cleansed skin.

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Mitchelle Morgan is a health and wellness writer with over 10 years of experience. She holds a Master's in Communication. Her mission is to provide readers with information that helps them live a better lifestyle. All her work is backed by scientific evidence to ensure readers get valuable and actionable content.

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