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Best Glutathione Supplements For Skin Whitening & Anti-Aging In 2023

Mitchelle Morgan

Updated on - Written by
Medically reviewed by Kathy Shattler, MS, RDN

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Life Extension Glutathione, Cysteine & C

Life Extension Glutathione, Cysteine & C

  • Non-GMO (genetically modified organism).
  • Promotes liver detoxification.
  • Prevents premature aging.

Bulletproof Glutathione Force

Bulletproof Glutathione Force

  • Emilimates myotoxins.
  • Supports the central nervous system.
  • Boosts brain function.

Puritan's Pride L-Glutathione 500 mg

Puritan’s Pride L-Glutathione 500 mg

  • Boosts liver health.
  • Brightens skin.
  • Rapid release capsules.

Everyone wants to look their best. And not only in dressing but also in how the skin looks. The skin is the biggest organ in the body and is undoubtedly the most exposed. So much so that people invest substantial amounts of money in skin health.

We are constantly buying anti-wrinkle creams and oils to cure numerous skin ailments. And on the other hand, we also invest in dietary supplements that are purported to be more effective than these topicals. Dietary supplements work from the inside to help the body flush out all the harmful compounds we consume daily and to provide essential nutrients for the body to function.

The list of health benefits from dietary supplements for the skin promises a ripple effect that also translates to liver health and the immune system, the body’s main detoxifiers.

This review covers all you need to know about the best glutathione supplement brands. Keep reading.

Best Glutathione Supplements For Skin Whitening & Anti-Aging in (June. 2023)

What is Glutathione?

Animals, plants, fungi, some bacteria, and some archaea all contain the antioxidant Glutathione[1]. Glutathione comprises three amino acids, gamma-glutamic acid, glycine, and cysteine. Our bodies create pure glutathione supplies naturally. About 90% of the glutathione levels within the cell are reduced l-glutathione.

Free radicals can be neutralized by the reduced form (GSH), which is the active state. The term “liposomal glutathione” describes glutathione that has undergone a unique process to encase the glutathione molecule within a lipid. This greatly increases absorption while safeguarding glutathione.

There are two states of glutathione: reduced (GSH) and oxidized (GSSG). An indicator of cellular oxidative stress is the proportion of reduced to oxidized glutathione, where a higher GSSG-to-GSH ratio denotes a higher level of oxidative stress.

When glutathione becomes oxidized, it loses its antioxidant properties. Glutathione can only work as an antioxidant adequately if it is reduced, which means it has the required electrons. And this is why supplements contain the reduced form of the compound.

Reactive oxygen molecules, including lipid peroxides, peroxides, free radicals, and heavy metals, can harm vital cellular constituents, but glutathione has the power to stop this from happening.

In addition to having the ability to expel and detoxify harmful compounds, glutathione is essential for maintaining youthful, healthy skin and promoting healthy aging. Additionally, it is a remarkable skin-brightening agent, a well-known compound for reducing wrinkles and fine lines and enhancing skin flexibility. 

Due to its incredible skin-protective characteristics, glutathione can be a real asset to your skin’s look and health. Glutathione has undergone a unique technique to encase the molecule within a lipid called liposomal glutathione. By doing this, glutathione is preserved, and bioavailability is greatly enhanced. 

Taking glutathione for a fairer skin complexion and brighter skin is among the most popular reasons why people use glutathione products such as capsules, liquids, or powders. But a more scientific reason that brands use to sell glutathione products is that it promotes healthy inflammatory responses, boosting immune health and its power in reducing oxidative stress to all body cells.

Deep within the body system, glutathione is a unique antioxidant because it can be recycled through the glutathione recycling pathway. The body naturally undergoes the glutathione recycling[2] process, where it is used over and over in the body following oxidation and reduction. This is great for your skin which typically needs healing and regeneration faster and more frequently than most organs.

A few factors may compromise glutathione production in the body. One of them being age[2]. Chronic diseases, alcohol, toxins, and a poor diet missing vitamin C[3] and sulfur[4] may also reduce the body’s glutathione levels. Glutathione supplementation is used to support healthy aging.

To curb deficiencies, you start by consuming foods high in glutathione[5], such as spinach, avocado, and asparagus, to increase glutathione levels. Taking milk thistle extract or alpha lipoic acid[6]– containing foods such as beets, carrots, and red meat may also boost[7] glutathione production. But after adding foods high in glutathione and finding you still need more, your registered dietitian may suggest using glutathione supplements. We briefly cover the top five brands and why they hold those positions.

Who Should Take a Glutathione Supplement?

Glutathione is composed of three amino acids that are vital for our survival. Nonetheless, a healthy person will have no issues with their glutathione levels if they are on a healthy diet.

However, people in the following groups may have to use the best glutathione supplements since their bodies produce glutathione at more negligible levels or not at all.

5 Best Glutathione Supplements to Buy in 2023

Life Extension Glutathione, Cysteine & C

Life Extension exclusively uses the finest raw resources. For more than 35 years, this company has assisted individuals in maintaining their health and living better. The foundation of their business has always been their conviction that greater nutrition can be achieved scientifically.

  • This supplement supports healthy skin aging.
  • It may help cure inflammation and health problems related to oxidative stress.
  • It promotes natural glutathione production in the human body.
  • It is a non-GMO and gluten-free supplement.
  • Marketed as a supplement to improve liver function.

Life Extension offers 50 milligrams (mg) of glutathione per serving as the best glutathione supplement on our list. They purport that this quantity will protect you and reduce oxidative stress and related issues.

The brand does not market this supplement mainly as a skin brightener, but they particularly push this product as a potent liver detoxifier. However, due to glutathione’s presence, people also use it for skin health.

The first ingredient is N- acetyl L-cysteine, a non-essential amino acid with numerous health advantages from protein synthesis[13] to glutathione formation[14]. Additionally, it contains extra reduced l-glutathione and vitamin C, which can neutralize free radicals, boost optimal iron assimilation[15], and defend your cells from oxidative stress, among other things.

N-acetyl-L-cysteine may lessen the adverse effects of skin aging. It might aid recovery following surgery or burns and shield the skin from radiation damage[16].

Cysteine may also promote muscle growth and fat metabolism[17].

Vitamin C has been shown in a few clinical tests to reduce wrinkles. According to one study[18], using a vitamin C formulation daily for at least three months reduced the visibility of fine noticeable lines on the face and neck while enhancing the texture and look of the skin.

So by taking this supplement, you may improve your physical health from the skin to the liver. With a well-working immune system, your skin may start to grow and thrive. To get the best out of this gluten-free supplement, take one capsule once or thrice daily on an empty stomach.

Bulletproof Glutathione Force

Our skins benefit greatly when the body naturally and effectively removes any free radicals that promote premature skin aging. The Bulletproof Glutathione Force promises to do that for you.

  • It boosts the central nervous system.
  • It may enhance brain function, memory, and cognition.
  • It is a potent body detoxification supplement.
  • It helps eliminate mycotoxins.
  • It is gluten-free.
  • It is expensive.

This glutathione supplement is efficient for your skin as it works internally to eliminate any component that promotes premature skin aging.

The Bulletproof Glutathione Force company claims to assist users in improving how well their internal organs function. It contains glutathione, a trio of strong antioxidants to protect our bodies from the impact of stress, poor food, and environmental pollutants. Taking this supplement every day may improve our general immune response systems and inhibit the free radical chain processes linked with these triggers.

Bulletproof Glutathione Force uses an expertly formulated proprietary mixture known as the activated liposomal delivery system to function. Glutathione’s bioavailability increases significantly with this novel delivery technique.

You should take one 500 mg glutathione capsule daily to stay within the recommended dosage.

Puritan’s Pride L-Glutathione 500 mg

Everyone seeks to get to optimal health, and Puritan’s Pride L-Glutathione may be the remedy you are looking for. The brand claims that the formula works from the inside out to boost the brightness of your skin.

  • It may brighten your skin.
  • It supports liver health through detoxification.
  • Puritan Pride’s L-Glutathione capsules come in a rapid-release capsule.
  • The brand offers a 90-day money-back guarantee.
  • The results of skin whitening may take a while to show.

One of the touted benefits of using this Puritan’s Glutathione supplement is a noticeable improvement in the appearance of one’s skin. In addition, the manufacturer claims that the supply of glutathione (reduced form) that you receive from purchasing their product is a robust immune system and liver booster. Each capsule has 500gm glutathione.

The most effective skin whitening capsules on the market today are known to contain glutathione, which has been referred to as the “master antioxidant” of the human body. The bleaching action of reduced l- glutathione is promising in and of itself, but this compound has many other beneficial effects on the body. 

This powerful whitening capsule not only makes your skin brighter but also makes your liver healthier and protects you from various health issues thanks to its antioxidant properties.

Codeage Liposomal Glutathione

This skin-lightening supplement contains only two powerful ingredients: L-glutathione and phospholipid complex from non-GMO lecithin and sunflower oil. This combo helps optimal health, including skin, heart, and liver.

  • Non-GMO.
  • It is dairy and gluten-free.
  • These liposomal glutathione capsules are free from any synthetic additives.
  • Manufactured in good manufacturing practices certified facility (cGMP) It may help support cardiovascular health.
  • Refunds are handled by Walmart instead of the company

The Liposomal Glutathione supplement from Codeage is a formulation that was developed to shield and support the activity of cells. It’s possible that liposomal glutathione can help sustain liver tissue and rejuvenate skin cells. These liposomal capsules may contribute to detoxing, immune health, improved mood, endurance, and muscular strength, as well as the general prevention of illness.

Phospholipids[19] are a distinct kind of chemical used to create a minuscule layering structure that takes the form of a bubble. This ingredient is vital in helping with cell membrane structure[20], liver function[21], and brain health.

High-quality glutathione (GSH) has been optimized so that it is ready to neutralize free radicals immediately after it gets into the system. Each dose is 500 mg.

Setria Glutathione included in this supplement is a potent tri-peptide that may support a range of functions, including enhancing energy levels, brain boost, and concentration focus, among others. It increases the glutathione level of essential tissues, including the skin.

Take one capsule with water or your preferred beverage to gain the most from this supplement. You should take it on an empty stomach for best absorption.

Thorne Glutathione-SR

If you are looking for a skin whitener that will also offer your eyes, heart, liver, and other body organs a boost in immune function, then the Thorne Glutathione SR might be what you are looking for.

  • It supports eye health and liver detoxification.
  • It reduces oxidative stress and brightens skin.
  • It may offer cardiovascular support.
  • It may help the body respond to physical activity.
  • This product is National Sanitation Foundation (NSF) certified for sports.
  • It is dairy, soy, and gluten-free.
  • Its price is on the higher side.

This dietary supplement provides an abundant supply of detoxifying antioxidants to the human body, which has various benefits, including the ability to brighten the skin[22] and provide support for the health of the lungs, liver, heart, eyes[23], and brain. It provides 175 mg of reduced glutathione per serving.

Glutathione may be beneficial to the eyes in helping to prevent ultraviolet light damage to the organ. It may also prevent eye dryness and some eye diseases while preventing the onset of cataracts. However, there isn’t must recent research on its effectiveness for eye health.

The sustained-release capsules use a proprietary formulation resistant to being broken down by the stomach acid.

Gluten and other common allergies are not included in any Thorne products because they are created with the finest ingredients. This item has no gluten, soy, yeast, dairy, fish, or shellfish in its ingredients.

Thorne has acquired the trust of hundreds of health practitioners, US National Organizations, individuals, and families worldwide due to its commitment to honesty and the production of products supported by science.

To get the best out of this supplement, take only two-three capsules daily or separate the glutathione dosage per your doctor’s guidance.

Benefits of Glutathione

Glutathione supplementation offers your body the following health benefits:

You must remember to observe caution when considering buying any of the above glutathione supplements for any remedy. Your physician must be the last person to give the go-ahead since many factors may help determine a supplement’s effectiveness.

Things like your condition’s cellular function, the rate of oxidative damage, and so much more are essential to your overall health. You also need to note that sometimes using skin supplements like collagen powders may affect the results achieved with any form of treatment.

On that note, your physician may also advise on the best form of glutathione to use, and how much glutathione to take for the optimal absorption of this powerful antioxidant

You should avoid this supplement if pregnant or breastfeeding.

What to Look For in a Glutathione Supplement

The supplement industry is riddled with hundreds of brands promising all the same things. So how can you be sure that your selection indeed reduces oxidative stress and gives your skin a healthy glow? Well, here is a list you may use to get the most out of your glutathione supplements:

  • The bioavailability of the glutathione form.
  • The included ingredients: sugar, gluten, preservatives, and dyes.
  • The product certification: GMP, Vegan, Organic, NSF, and other certifications.
  • The glutathione dosage.
  • The value you get against the price.


Glutathione dosages vary according to the reason you are using the supplement. On that note, the recommended dosage of glutathione for skin brightening varies. Dosages[31] range from 50-600 mg. 

When it comes to skin brightening, individual differences in metabolism, weight, overall health and other factors affect how much glutathione is ultimately assimilated. Your skincare objectives should also be considered if you want to change more than a few shades.

Research[32] suggests that 500 mg of glutathione will have a skin whitening effect on humans. Oral doses[33] in amounts of 250 mg positively affect skin tone and elasticity. Contraindications[34] to its administration have not been identified, although there are mild interactions with about 89 different drugs.

There are some risks to using Glutathione long-term. It may cause asthma attacks in those using aerosol treatments, and it may also lower body zinc levels. Other possible side effects are stomach cramps, bloating, and skin allergic reactions like rashes and hives.

Final Thought

These five glutathione supplements are just a few in a line-up that offers equally great health benefits for the skin and other organs. Besides helping you get brighter and blemish-free skin, you also celebrate overall health with healthy glucose levels in check, healthy blood circulation, and good liver and kidney help for detoxification. The brain and the eyes also get a piece of the glutathione health benefits.

Taking supplements must be done under the supervision of your doctor. And while you are at it, ensure to incorporate natural foods that will boost glutathione production like milk thistle extract and alpha lipoic-rich foods. And with that, you may finally feel great and look great too.

Frequently Asked Questions

Does glutathione help lighten the skin?

Yes, it may lighten the skin by fighting off oxidative stress on the skin cells, reversing UV damage, and revitalizing skin cells to gain a better and fairer complexion.

When is the best time to take glutathione?

Glutathione intake is best on an empty stomach or before a big meal. This enhances its absorption.

Is it safe to consume glutathione daily?

There are no identified contraindications to taking glutathione, and the daily dose[31] is 50- 600 mg.

Is there any risk to using glutathione?

Yes, there are. Long-term glutathione usage may cause asthma attacks in those using aerosol treatments and lower body zinc levels.

How many glutathione injections should I take?

Glutathione injections should be administered 1-3 times weekly for 4–8 weeks. If you decide to keep getting the injection after this period, it will depend on how well you respond to the treatment. The current clinical evidence[1] for IV injections for skin lightening is limited to one study, hardly enough to make any clinical conclusions.

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Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

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Mitchelle Morgan

Medically reviewed by:

Kathy Shattler

Mitchelle Morgan is a health and wellness writer with over 10 years of experience. She holds a Master's in Communication. Her mission is to provide readers with information that helps them live a better lifestyle. All her work is backed by scientific evidence to ensure readers get valuable and actionable content.

Medically reviewed by:

Kathy Shattler

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