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Best Diet Pills 2022: Top 7 Weight Loss Supplements

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Medically reviewed by Melissa Mitri, MS, RD

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PhenQ Supplement

PhenQ

  • Speeds metabolism to burn fat
  • Blocks production of new body fat
  • Curbs appetite and boosts energy

Up To 50% Off When Buying In Bulk

Leanbean

LeanBean

  • Glucomannan increases feelings of fullness
  • Increase fat burning with thermogenic ingredients 
  • Green coffee bean extract boosts energy

PhenGold

PhenGold

  • Fewer side effects than many diet supplements
  • The multi-action formula boosts fat loss
  • Reduces cravings, increases metabolism and energy

Up to 55% Off When Buying in Bulk

Obesity rates[1] around the world have reached epidemic proportions, now affecting more than 2 billion people. While excess weight can certainly be a self-esteem issue for many, it can also have devastating effects on your health. 

People who are overweight or obese have a higher risk for chronic health issues[2] like type 2 diabetes, coronary heart disease, high blood pressure, and sleep apnea. Obesity can also negatively affect mental health and lead to reduced quality of life. 

Unfortunately, many people who want to lose weight have a difficult time doing so. Counting calories and spending hours in the gym every week sometimes just isn’t enough. The best diet pills may be able to give you that extra push to lose weight and achieve your wellness goals. 

Best Diet Pills for Weight Loss in (September. 2022)

How Do Diet Pills Work?

Weight loss supplements are simply dietary supplements that help you lose weight. They come in a variety of different forms such as appetite suppressants, thermogenic fat burners, carb blockers, and fat blockers. The best weight loss diet pills contain scientifically supported ingredients like Garcinia cambogia extract, raspberry ketones, glucomannan, green coffee bean extract, and more. 

While no weight loss supplement can take the place of a sedentary lifestyle and a high-calorie diet, the right weight loss pills can boost the effects of a healthy weight loss regimen. 

This article reveals some of the most effective weight loss supplements to help you shed body fat and achieve healthy body weight. We’ll also cover some important tips for choosing a diet pill based on ingredients, brand reputation, and customer experience. 

The Line Up At A Glance

PhenQ Supplement

Editor’s Choice

PhenQ

  • Speeds metabolism to burn fat
  • Blocks production of new body fat
  • Curbs appetite and boosts energy

Up To 50% Off When Buying In Bulk

Leanbean

Best For Women

Lean Bean

  • Glucomannan increases feelings of fullness
  • Increase fat burning with thermogenic ingredients 
  • Green coffee bean extract boosts energy

phengold

Fewest Side Effects

PhenGold

  • Fewer side effects than many diet supplements
  • Multi-action formula boosts fat loss
  • Reduces cravings, increases metabolism and energy

Up to 55% Off When Buying in Bulk

instant knockout

Best for Men

Instant Knockout

  • Made in the USA from all natural ingredients
  • No proprietary ingredients 
  • Strong thermogenic fat burner

burn lab pro

Best Metabolism Booster

Burn Lab Pro

  • Burn fat and boost metabolism 
  • Supports muscle growth and recovery
  • Increases energy to fuel workouts

Trimtone

Best Appetite Suppressant

Trimtone

  • Green tea extract to increase metabolism
  • Glucomannan helps suppress appetite and cravings
  • Easy once a day capsule

PrimeShred

Best for Fat Burning

PrimeShred

  • Lose weight without fatigue or muscle loss
  • Made with clinically backed ingredients
  • High potency formula for shedding fat

7 Best Weight Loss Diet Pills for 2022

PhenQ

PhenQ Supplement

Up To 50% Off When Buying In Bulk

See LeanBean Reviews

Not only is Leanbean one of the top diet pills for women, but it is also our top pick for the best diet pills for women over 50.

  • Glucomannan increases feelings of fullness
  • Increase fat burning with thermogenic ingredients 
  • Green coffee bean extract boosts energy
  • May not work as well for men
  • No subscription option

Tailored specifically to women, Leanbean is a powerful appetite suppressant that helps reduce food cravings. Free from harmful stimulants, this formula contains 3g of clinically proven[7] Glucomannan, a natural fiber used in the most popular weight loss pills to keep you feeling fuller for longer. When you feel full, you’re less likely to snack and overeat. 

Leanbean is an effective weight loss supplement when used in conjunction with a healthy diet and active lifestyle. In addition to suppressing appetite, this diet pill supports the fat-burning process through natural thermogenic ingredients like choline[8]

It also contains a special vitamin complex that boosts energy and focuses to help you lose weight and feel great. 

This natural appetite suppressant comes with a 90-day money-back guarantee and every order ships free around the world. Save more when you buy a bundle.

PhenGold

phengold

Up to 55% Off When Buying in Bulk

See PhenGold Reviews

Most weight loss pills come with a certain level of risk for side effects, but PhenGold is said to be tolerated well by most users. It’s also one of the most effective diet supplements on the market. 

  • Fewer side effects than many popular weight loss supplements
  • Multi-action formula boosts fat loss
  • Reduces cravings, increases metabolism and energy
  • Availability is somewhat limited
  • Caffeine content may be too high for some

Before taking any kind of dietary supplements or prescription medications, you should consider the risk for side effects. Even natural weight loss pills come with some degree of risk, but PhenGold seems to have minimal side effects, according to customer reviews.

This weight loss pill features a multi-action formula that torches fat cells by supporting the body’s natural ability to burn fat. 

In addition to burning fat, PhenGold reduces cravings, increases metabolism, and helps stabilize mood and energy. It contains clinically proven ingredients and is backed by a 100-day money-back guarantee. This weight loss pill ships free throughout the world and, if you order a 2-month supply, you’ll get an extra month free. 

Paired with a balanced diet and regular exercise program, PhenGold can help you avoid weight gain and achieve your fitness goals. It is soy, gluten, and dairy-free in addition to being vegetarian and vegan-friendly. 

Instant Knockout

Supported by pro athletes, Instant Knockout is our pick for the best weight loss pill for men. It supports weight loss by boosting metabolism, increasing fat burn, and controlling appetite.

  • Made in the USA from all-natural ingredients
  • No proprietary ingredients 
  • Strong thermogenic fat burner
  • Fairly expensive
  • Caffeine content may be too high for some

If you’re trying to achieve a chiseled physique, it may take more than just losing weight. 

Regular exercise and a strong workout routine can help you achieve healthy body weight and build muscle. But if you still need a little extra help, Instant Knockout is just what you need. 

This weight loss supplement features scientifically proven ingredients to help you cut and shred fat, speed your metabolism, and reveal sculpted muscle. It is free from proprietary ingredients in a simple, clear-cut formula. Proprietary ingredients consist of multiple ingredients but they can be listed as a blend on the label without the company having to disclose the doses of the individual ingredients.

Instant Knockout is made in FDA and cGMP-approved facilities and every ingredient is meticulously researched to ensure optimal results. 

Instant Knockout is made in the USA with all-natural ingredients and is certified vegan-friendly. Your order will ship the same day for free.  You can save further by opening an account and starting a monthly subscription.

Burn Lab Pro

burn lab pro

The secret to weight loss is burning more calories than you consume. Along with diet and exercise, a metabolism booster like Burn Lab Pro can help you achieve significant weight loss.

  • Burns fat and boosts metabolism 
  • Supports muscle growth and recovery
  • Increases energy to fuel workouts
  • Some users experience stomach upset
  • HMB may cause reactions in some

Burn Lab Pro is formulated to help you torch fat and maintain muscle, all while feeling strong. It is a 100% safe, natural formula free from stimulants that comes in easy-to-administer vegan capsules. 

This weight loss supplement is beloved by competitive weightlifters and athletes, but it can help you lose weight even if you’re just getting started on your weight loss journey.

This weight loss pill supports weight loss without you having to endure a low-calorie or low-fat diet. 

It also supports muscle growth and recovery, enabling you to work out at a higher intensity. It also helps protect lean muscle gains, which supports a faster metabolism. This formula also helps you lose belly fat by supporting the process of thermogenesis, a process that boosts metabolism and increases calorie burn. 

Burn Lab Pro comes with a 30-day risk-free trial – if you don’t love it, you can return it for a full refund with no questions asked. All orders include fast, free shipping. 

Trim Tone

Trimtone

Weight loss is difficult to achieve when you’re hungry all the time, but that’s where an appetite suppressant comes in. Trim Tone helps curb cravings to helps you maximize your weight loss benefits.

  • Green tea extract to increase metabolism
  • Glucomannan helps suppress appetite and cravings
  • Easy once a day capsule
  • Contains high levels of stimulants
  • Not vegetarian or vegan-friendly

Trim Tone is one of the best diet pills for belly fat because it helps you burn more calories naturally. In addition to firing up fat loss by boosting metabolism, this diet pill suppresses your appetite to keep you on track. 

Designed to be taken once a day, this weight loss pill is best taken before breakfast with water.

Made from all-natural ingredients, Trim Tone doesn’t contain any unnecessary or synthetic ingredients. The main active ingredients include caffeine, green coffee beans, green tea extract, grains of paradise, and glucomannan. 

Just to make sure you’re happy with your weight loss results, Trim Tone also offers a 100-day guarantee.

If you’re shopping for the best diet pills for belly fat, consider Trim Tone. Get fast, free shipping when you order a two-month supply and receive an extra month free. 

PrimeShred

PrimeShred

Formulated with clinically backed ingredients, PrimeShred is our pick for the best thermogenic fat burner. Its high potency formula helps you lose weight without losing muscle mass.

  • Lose weight without fatigue or muscle loss
  • Made with clinically backed ingredients
  • High potency formula for shedding fat
  • Some people experience stomach upset
  • Somewhat expensive

Losing weight can be an exhausting process and many of the top weight loss supplements only help you shed fat cells. PrimeShred is different because it helps you lose weight without losing energy or muscle mass. 

This weight loss pill supports increased calorie burn by boosting your metabolism, which may help you achieve your desired results even faster.

In addition to shredding fat cells, PrimeShred can amplify your energy and mental focus. No matter how often or how long you work out, you may notice less fatigue compared to how you have felt on other weight loss pills. 

Plus, a unique mood-boosting complex is included to help you feel great day after day. 

PrimeShred features a 100% transparent formula that is free from GMO ingredients and is made in the USA. It doesn’t contain artificial additives and it’s backed by a 100-day guarantee.

Tips for Choosing Best Diet Pills for Weight Loss

When it comes to losing weight, a healthy diet and exercise are a must. Consuming more calories than you burn on a daily basis will cause weight gain, and even the best weight loss pills won’t be able to counter that. 

The right weight loss pill can help with appetite suppression and fat burning to help you lose weight more quickly than diet and exercise alone.

If you’re planning to start a weight loss journey, talk to your doctor first. Your doctor can help you determine how much weight you need to lose and the rate at which it is safe to lose it. 

You can also talk to your doctor about prescription weight loss pills versus over-the-counter (OTC) weight loss supplements. A prescription weight-loss drug may be recommended for individuals who are obese, while OTC weight loss pills may be best for those seeking modest weight loss. 

Whether prescription or OTC, all weight loss pills are not created equal. As you start shopping around, here are some things to look for:

Natural Ingredients

The best weight loss pills are made from all-natural ingredients that are clinically proven to deliver results. You should avoid any weight loss medication or supplement that contains unsafe ingredients. 

Ingredients like ephedrine[9] and pseudoephedrine, for example, can impact the nervous system and cause irregular heartbeat, increased blood pressure, and even heart attack or stroke. Ephedra has been banned in the US but is still in some diet supplements sold abroad. 

In addition to looking for natural ingredients, consider any dietary restrictions you may have. Many weight loss pills come in vegan capsules and are also gluten-free. Double-check the list of ingredients before you buy if you have food allergies or sensitivities.

Clean Label (No Proprietary Blends)

Before you purchase any dietary supplements, read the label. While the FDA doesn’t regulate supplements in the same way they do prescription drugs, companies are still required to put certain information on product labels. You’ll be able to find dosing recommendations, a full list of ingredients, and values for active ingredients. 

As you peruse the list of ingredients, be on the lookout for proprietary blends. While it may sound like a good thing that a company has created its own formulation of active ingredients, many companies use this strategy as a loophole. By listing the blend as an ingredient, they can get away without disclosing the actual dosages of the ingredients in that blend. 

Money-Back Guarantee

There are no guarantees that a weight loss supplement will work. If you don’t do the work to improve your diet and burn calories through exercise, you probably won’t lose much weight. That being said, if you choose to add a weight loss pill to your regimen, it’s worth picking one that comes with a money-back guarantee for peace of mind. 

A money-back guarantee simply gives you the option to return the product for a refund within a certain time frame after purchase if you’re not happy with the results. These guarantees generally range from 30 to 100 days. Just keep in mind that the length of the guarantee may vary depending on the number of bottles you purchase. 

Brand Reputation

If you’re going to be putting something in your body, you want to know that it’s safe. While many dietary supplements don’t have a lot of clinical research behind the specific product, the good ones are made with ingredients that are clinically tested. 

Look for a company that provides scientific data on how their product works or, at the very least, evidence that supports the use of the main ingredients in the product.

It’s also worth checking to see where and how the product is manufactured. A brand made in the USA is subject to FDA standards. Some brands also opt to put their products through additional testing for potency and safety, which is another sign of a high-quality brand. 

Positive Reviews

In addition to verifying the brand’s reputation, you should look up reviews for the specific product. You can do this by simply performing an internet search for the product name plus the word “reviews.” 

While many brands will post customer reviews on their website, there’s no guarantee that they aren’t sponsored reviews. Some companies will also choose to feature positive reviews and omit negative ones. This is why doing a full Internet search is helpful to find a wider variety of reviews that are unbiased.

Final Thought 

If you’re in the market for the best weight loss pill, you now have 7excellent options to consider. These supplements are made with effective natural ingredients and formulated to help you burn fat and fight cravings to achieve your weight loss goals. 

When shopping for weight loss pills, be sure to do your research so you know exactly what you’re buying. Read the list of ingredients, verify the brand’s reputation, and read customer reviews. 

And remember, if you’re not satisfied with the results, most companies offer a money-back guarantee to protect your purchase.

With that, we hope that one of the best diet pills for weight loss pills will help you achieve the healthy body of your dreams. 

Frequently Asked Questions

How do weight loss pills work?

Dietary supplements for weight loss work by suppressing appetite, increasing normal fat metabolism, and boosting energy levels. They support weight loss in conjunction with a healthy diet and exercise.

Are weight loss pills safe?

Generally, though it depends on the ingredients. Even the best weight loss pills come with a risk for side effects, but the benefits may outweigh the risks. This can be especially true if you’re already experiencing health problems related to obesity.

What are the best diet pills for weight loss?

The best weight loss pills are made from natural ingredients that are backed by clinical evidence. They do not contain high levels of stimulants or excessive amounts of proprietary ingredients, and they are made by a reputable company.

How are prescription weight loss drugs different from weight loss supplements?

A prescription weight loss pill can provide various benefits from appetite suppression to blocking some of the fat you consume from being absorbed. Prescription weight loss medication is usually reserved for individuals with a BMI over 30 or those with weight-related health problems.


+ 9 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

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  2. CDC. Adult Obesity Causes & Consequences. Centers for Disease Control and Prevention. Published March 22, 2021. Accessed February 18, 2022. https://www.cdc.gov/obesity/adult/causes.html
  3. Whiting S, Derbyshire E, Tiwari BK. Capsaicinoids and capsinoids. A potential role for weight management? A systematic review of the evidence. Appetite. 2012;59(2):341-348. doi:10.1016/j.appet.2012.05.015
  4. Anton SD, Morrison CD, Cefalu WT, et al. Effects of Chromium Picolinate on Food Intake and Satiety. Diabetes Technology & Therapeutics. 2008;10(5):405-412. doi:10.1089/dia.2007.0292
  5. Graham TE. Caffeine and Exercise. Sports Medicine. 2001;31(11):785-807. doi:10.2165/00007256-200131110-00002
  6. Pooyandjoo M, Nouhi M, Shab-Bidar S, Djafarian K, Olyaeemanesh A. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obesity Reviews. 2016;17(10):970-976. doi:10.1111/obr.12436
  7. Maia-Landim A, Ramírez JM, Lancho C, Poblador MS, Lancho JL. Long-term effects of Garcinia cambogia/Glucomannan on weight loss in people with obesity, PLIN4, FTO and Trp64Arg polymorphisms. BMC Complementary and Alternative Medicine. 2018;18(1). doi:10.1186/s12906-018-2099-7
  8. Hongu N. Carnitine, Choline and Caffeine Promote Fat Loss and Metabolism Carnitine, Choline and Caffeine Promote Fat Loss and Metabolism in Rats and Humans in Rats and Humans. Accessed February 18, 2022. https://trace.tennessee.edu/cgi/viewcontent.cgi?article=5481&context=utk_graddiss
  9. Shekelle PG, Hardy ML, Morton SC, et al. Efficacy and Safety of Ephedra and Ephedrine for Weight Loss and Athletic Performance. JAMA. 2003;289(12):1537. doi:10.1001/jama.289.12.1470

Medically reviewed by:

Kate Barrington holds a Bachelor’s degree in English and is the published author of several self-help books and nutrition guides. Also an avid dog lover and adoring owner of three cats, Kate’s love for animals has led her to a successful career as a freelance writer specializing in pet care and nutrition. Kate holds a certificate in fitness nutrition and enjoys writing about health and wellness trends — she also enjoys crafting original recipes. In addition to her work as a ghostwriter and author, Kate is also a blogger for a number of organic and natural food companies as well as a columnist for several pet magazines.

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